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When it comes to under-the-radar killers, sepsis is at or near the top of the list. It can begin quietly, often looking like the flu, pneumonia, or a urinary tract infection. And then it escalates, quickly erupting into widespread infection and inflammation that can cause organ failure and death if not treated fast enough.

Sepsis accounts for one-third to one-half of all deaths that occur in US hospitals, or between 225,000 and 350,000 deaths a year. That puts it right behind heart disease and cancer as a leading cause of death among Americans. Yet sepsis barely gets mentioned in the press and hasn’t attracted a fraction of the research interest as heart disease and cancer. New research published Monday in JAMA is a welcome addition.


Dr. James WeinsteinLike other academic medical centers, Dartmouth-Hitchcock Medical Center treats patients with sepsis all the time. Sometimes it is detected in the emergency department, often among patients who have been transferred from other centers because they are going downhill fast. Sometimes it crops up in patients who were admitted to the medical center for something else, like kidney problems or an operation, but who picked up a bug that morphed into serious infection. It could be an adolescent or a 90-year-old with cancer receiving immunosuppressive therapies that make them more susceptible to a life-threatening infection such as sepsis.

Because of the different streams of patients, we didn’t realize the full effect that sepsis was having on our patients. When we took a close look at it in 2014, we were very troubled to learn that nearly half of the patients who came to Dartmouth-Hitchcock with sepsis, or who developed sepsis in our hospital, died; the national average is between 35 percent and 60 percent.

I called together clinicians and other experts from various parts of the medical center and said we needed to fix deaths from sepsis ASAP, meaning before six months had passed. With a $26 million innovation grant from the Centers for Medicare and Medicaid Services, collaboration from our partners in the High Value Healthcare Collaborative, and some exhaustive work, we did just that — our death rate from sepsis dropped by more than 75 percent.


The solution wasn’t fancy; there was no code to break. We simply made sure that all clinicians were aware of the warning signs of sepsis and set a low threshold for starting treatment. We also standardized treatment, adopting the evidence-based “three hour bundle.” That means doing the following things within three hours of suspecting that someone might have sepsis:

  • taking a blood sample to measure lactate, a byproduct of turning blood sugar into energy. A high serum lactate level is a sign of severe metabolic distress
  • culturing the blood to identify infection
  • starting the patient on a broad-spectrum antibiotic
  • keeping him or her well hydrated

As our use of the three-hour bundle went from 0 percent to 90 percent over a three-month period, deaths from sepsis plummeted — in the first two months of the initiative, we had no deaths from sepsis.

Dr. Andreas Taenzer, a Dartmouth-Hitchcock anesthesiologist, led the effort. When he presented the results to our board of trustees, with tears in his eyes he told them it was one of the most rewarding things he had done in his career.

Our mission now is two-fold: First, we need to scale and spread our work. We have begun to raise awareness of sepsis among community hospitals, primary care practices, and emergency responders. Getting them to identify people who might have sepsis before it gets out of hand would let treatment start sooner and avoid unnecessary transfers and more expensive hospitalizations at tertiary medical centers. Second, we need to spread the word about the three-hour bundle. A grant from the Laura and John Arnold Foundation will help us do this among the 17 High Value Healthcare Collaborative health delivery systems, which collectively serve more than 70 million Americans. A goal of national dissemination will follow. Ultimately we hope our work will have a global reach.

The move to redefine sepsis, as described in Monday’s JAMA, will help rein in this complex condition. Widely applying the three-hour bundle will go even further toward preventing the vast majority of deaths from it.

Dr. James N. Weinstein is chief executive officer and president of Dartmouth-Hitchcock. It includes New Hampshire’s only academic medical center and a network of clinics across Vermont and New Hampshire that serve 1.9 million patients. His book, “Unraveled: Prescriptions to Fix a Broken Health Care System,” will be published in February 2016.

  • Aloha,

    My dad is currently hospitalized for an infection in his blood & it does not look good as his first round of antibiotics caused him to break out with a rash, swelling and pain.
    A few years back he had a bout with MRSA that got to his bone. He did not do well with 3-4 different antibiotics, before they finally found one that finally cleared the infection. Wondering if their are any suggestions or recommendations that would be helpful for my dad and our family.


  • Im from South Africa.My twin brother have had an operation a month ago. Currently he receive treatment for sepsis a41.9 . His infection count was a week ago 102 and dropped to 37 a few days later but it increace to 49 on day 8. He is on a liver and kidney machine. What can be done to cure the infection. PLEASE HELP/ASSIST URGENTLY

  • I had sepsis from a kidney stone. I’ve been out of the hospital since November of 2018. I’m still having so much trouble with my muscles and joints hurting. The doctors in my area act like I’m not sick. They have no clue what’s going on.

  • I have a friend that’s in Clinton sparrow memorial hospital that has sepsis they have not transported him and he’s getting worse. He is the only patient in this hospital and he’s not getting the care he needs. Please he needs help he has insurance and I believe he’s not getting the treatment he’s suppose to get. They are neglecting his needs.

  • Patients are still dying of Sepsis at St. Joseph’s Hospital in Nashua. My husband is one of them. He was never treated for Sepsis and I was never told he had it. I had to find out from the Undertaker. How sad is that?

  • This is a stunning advance in the treatment of sepsis. The three hour bundle is a genius in its intellectual simplicity! Thank you to Doctor Andreas Taenzer and Dartmouth-Hitchcock Medical Center for developing this life saving protocol. …and for urgently spreading the word.

  • My Dad passed away from sepsis. I was told he wasn’t terminal. I’m researching & my Dad had all the signs & symptoms. I feel like a advocate for my Dad. Hospitals,nursing homes, doctors & specialist need advance training in sepsis prevention & treatment. I pray society as a whole steps up to stop, prevent sepsis asap. How can so many medical professionals miss so many symptoms? Alarming to say the list. I questioned every symptom & was told my Dad was just depressed. My heart ached so much as I held my Dads hand as he passed away Nov. 16th 2016. I pray for some understanding, as I feel I live in a ongoing nightmare. God give strength to everyone whose lost a loved one to something that should have been prevented or caught sooner.

    • I feel the same my niece been intensive care once with sepsis shock .the got it again when let home from hospital .she been in the royal free hospital hampstead now for months and now she has sepsis again unless people that work there have no clue about anything .i need help b4 my niece dies if it ain’t to late already.

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