There’s a lot of hype these days over nanoparticle-based cancer treatments, which try to shoot minuscule packages carrying drugs right to tumors. While many have succeeded in mice, very few have actually worked in clinical trials. Biochemist Warren Chan and his colleagues wanted to see how often those nanoparticle efforts fail, and what, if anything, could change that. Here’s what he said about the analysis, published in Nature Reviews Materials.
How often did those treatments fail in humans?
We asked a very simple question: How many nanoparticles actually get into the tumor? We scoured the literature from the last 10 years. It’s about 0.7 percent — that efficiency is very low. Usually, people inject millions or billions of nanoparticles, but still the fact that less than 1 percent goes into the tumor speaks volumes about the concept of targeting.
How do you address that?
We have to figure out what’s going on at the beginning. We know the outcome works in animals, but we don’t know how we get to that positive outcome. All these different things in the body attack the nanoparticles and try to filter them out. If we can better understand how they get filtered, then we can design our particles around those traps.
About the Author Reprints
There is the chance that the individual may control efficiently the occurrence and development activity of malign cells.
The tumor cells and the disturbances caused by them represent a very complex problem with various unknown elements which make difficult the doctors’ efforts and the patients’ expectancies.
All information held by the human being until now about the tumor cells are insufficient in order to sole efficiently the malign affections. To this effect, we have to enlarge the knowledge horizon by new „key” information and I have not renounced and I have made this with all my passion and power – in the research study named „All about the malign cells and their fighting”. Now, the importance of the new discoveries may have a significant impact on our anti-tumor defense.
I have not created this work in order to impress somebody. The thing in stake might be even our lives. I wanted that the people be fully aware of the mechanism generating the occurrence and development of malign affections, as well as the main liable agent so that the human being may redirect and adapt its efficient, preventive defense strategy against malignity.
It is not easy to carry out such a complex scientific research in an inaccessible field, located beyond the knowledge limits and to succeed revealing some unknown biological mechanism of malign cells and vulnerable „key” points of their behavior which might be selectively attacked.
I am not an English speaker, I have no support and the translation and editing costs are large, especially to support and continue the fundamental applicative scientific activity of tumor cells.
I am sorry that such new information and solutions cannot reach the audience much more quickly in order to improve, to test them legally and to obtain the copyrights license.
While most people is waiting, hoping for years to have something new which may heal them, this new information stays hidden within my papers and documents, having no chance to be known and useful. I am looking for a suggestion and help in order to reveal them to the world, to continue the activity and release one of the four books named „Life beyond all” which includes everything about malign cells and their fighting against (400 pag.).
Thank you for your attention and support.
Sincerely yours,
The author of these works
Nicolae Gheorghe
ROMANIA
E-mail: [email protected]