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Gonorrhea may soon become untreatable.

The Centers for Disease Control and Prevention reported Thursday that the wily Neisseria gonorrhoeae bacteria may be developing resistance to the only two antibiotics left that can cure the sexually transmitted disease.

The drugs, azithromycin and ceftriaxone, are used in combination to treat gonorrhea, a strategy experts hope will prolong the period during which these critical drugs will work.


But a nationwide surveillance program showed rises in the percentage of gonorrhea samples that were resistant to one or the other drug in 2014. In the case of azithromycin, there was a fourfold rise in the portion of samples that were resistant.

The rates are still modest: the percentage of samples resistant to azithromycin rose from 0.6 percent to 2.5 percent, and for ceftriaxone it doubled, from 0.4 percent to 0.8 percent. But these are red flags for scientists tracking gonorrhea’s march through the antibiotic armamentarium.


“It is low. But what we do know is that this bacteria has demonstrated the ability, repeatedly, to develop antibiotic resistance to the drugs that have been used for it,” the first author of the report, Dr. Robert Kirkcaldy, told STAT.

“The potential for untreatable gonorrhea is a very real possibility in the future.”

Gonorrhea is common. In 2014, more than 350,000 people in the United States were diagnosed with it. People who are infected may have no symptoms, or may notice pain, burning, or discharge, in the site of infection — usually the uterus, anus, throat, mouth, or penis.

Left untreated, it can cause infertility or chronic pelvic pain in women, and in men, testicular pain and infertility in rare cases. The bacteria can also get into the blood, infecting joints, and on rare occasions can move into the heart — which can be fatal.

An infected pregnant woman can infect her infant during childbirth; the baby can develop an eye infection that can be vision-threatening.

Since the dawn of the antibiotic era, these bacteria have been steadily mowing down every antibiotic placed in their path, Kirkcaldy said.

Where resistance was seen to azithromycin or ceftriaxone, the infecting strain was still susceptible to the other drug and the cases were cured, he said. But the specter of pan-resistant gonorrhea looms large.

“We think … it’s a matter of when and not if with resistance,” he said. “This bug is so smart and can mutate so rapidly.”

Dr. Vanessa Allen agrees. The chief medical microbiologist for Public Health Ontario, Allen has been tracking the development of resistance in gonorrhea for some time. The rates Ontario is seeing for these drugs is similar to what the CDC is reporting, she told STAT.

“It doesn’t seem to be a blip in the Ontario context,” said Allen, who has more recent data than the CDC report analyzes. Resistance “seems to persist.”

Kirkcaldy said one of the things that makes gonorrhea so difficult is that once it acquires resistance to a drug, it doesn’t appear to lose it. The bacteria are still invulnerable to antibiotics that haven’t been used to treat it for decades.

Kirkcaldy declined to speculate on how quickly the bacteria may acquire the ability to evade these azithromycin and ceftriaxone, saying it’s too hard to predict.

Using the combination therapy should buy more time. Allen said the report is heartening as it suggests US doctors have rapidly adopted the combination therapy, as recommended by CDC.

Some companies are working on new antibiotics, “but these could be years away,” Kirkcaldy said.

In the meantime, it’s critical to get people to start taking the threat seriously, he said, so that they take steps to prevent themselves from being infected with gonorrhea.

“The trend is known,” said Allen. “At some point, it’s just: How much can we slow it down?”

“It will happen and we don’t have any other options.”

  • Pls help l’m living with this disease for three now and l’m injected with ceftriaxon 2g more five times now, but l’m still linving with the disease. Doctors have failed to treat, please help

  • At the onset of WWII, with so many males contracting GC, the treatment was urethral irragation with tincture of methiolate. Very painful and this did not necessarily prevent subsequent urethral scarring. I can well recall passing urethral sounds on males when I was an intern. Penecillin showed up and was very effective back in the 1940’s. Looks like we may be back to methiolate again and seeing other GC complications, like gonococcic arthritis.

  • life will be thought in the next 10 years, because teen become sexual active in the early age (12 years). but as a future scientist I believe that I will came with another antibiotic….”as I know other tree that treat Gonorrhea”………..student of university of Venda (South Africa)… Biochemistry and Microbiology.

  • Sam,
    Just because promiscuous behavior and adultery has been present throughout time does not mean that it is right and just fine to engage in. Perhaps if no one helped these people they would see the end results of their behavior. It’s an artificial lifestyle propped up by drugs and without them these people would die of their own STDs.

  • Cepheid makes a test that can detect NG in 90 minutes providing the opportunity to test and treat appropriately while the patient is present.

  • If they didn’t continue to promote and encourage the lifestyle that causes this disease, we wouldn’t have to worry about it.

    • Who are “they”?
      And people have been promiscuous since the beginning of time.
      This comment is laughable.

      Where do you think the word “Bastard” come about? Men have been cheating on their wives with maids, prostitutes etc since the beginning of time.

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