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For decades, Sharon Samuels struggled with simple everyday tasks like brushing her teeth, buttoning her shirt, putting on makeup, and eating food.

“I did not want to go out socially with other people, especially people who I did not know, because I could see them looking at me. And the feeling was horrible,” she recalled. “It would take my heart away when I was trying to eat and I’d look up and they were looking at me.”

Samuels, 72, has essential tremor, a movement disorder characterized by uncontrollable shaking mostly in the hands or legs. An estimated 10 million people in the United States suffer from the condition, according to the International Essential Tremor Foundation. The disorder isn’t fatal, but it tends to get worse with age and to affect patients’ quality of life.


Doctors usually treat essential tremor with medication, but the drugs don’t work well for all patients. Now a new trial finds that a treatment to kill off neurons in a certain region of the brain can do away with tremors in some patients who don’t respond to drugs. But the procedure brings lasting side effects in some patients, and its long-term usefulness is still being studied.

In an ongoing clinical trial at 11 medical centers globally, researchers are using ultrasound waves to treat the source of essential tremor in the brain. The therapy, called focused ultrasound thalamotomy, uses the energy generated by sound waves to burn off certain cells in the thalamus, a region of the brain where the essential tremor is thought to originate.


Patients are placed in an MRI machine with their head secured in place in a special helmet. They are awake as doctors aim over 1,000 low-energy ultrasound waves to create a lesion — an injury to the tissue — inside the thalamus.

“As we make the test lesion, we see a subtle improvement in their tremor and the patients notice it,” said Dr. Rees Cosgrove who is leading the trial at Brigham and Women’s Hospital in Boston. Brigham is one of the six centers running the trial in the US.

“As we enlarge the lesion, the tremor just stops and they’ll just look at their hand. It has been shaking for years and they look at it as though, ‘Hmm, is this really my hand?’ It’s really a remarkable moment.”

For Samuels, who underwent the procedure on June 29, the recovery has been surprising. She had been taking tremor medication for almost a decade with little improvement. After the procedure, which only focused on her left hand, her tremor there has almost disappeared.

“This has changed the quality of my life,” she said. “Now, it’s a pleasure, I can sign my name, I can write. I can eat like a normal person, doing things that I couldn’t do before.”

Sharon Samuels performs an Archimedes spiral drawing test before and after her treatment for essential tremor in her left hand. Suzanna Masih and Hyacinth Empinado/STAT

In July, the Food and Drug Administration approved the device being used in the trial. It has been developed by InSightec, which is funding the trial along with the Focused Ultrasound Foundation and the Binational Industrial Research and Development Foundation.

A pilot study on MRI-guided focused ultrasound treatment was published in 2013.

The randomized trial provides further data on the treatment. In the study, published in the New England Journal of Medicine on Wednesday, 76 patients were treated with focused ultrasound, and their tremor was evaluated after the first, third, sixth, and 12th month. Researchers found that the severity of essential tremor reduced significantly over that time in the patients who underwent the treatment versus those who had a sham procedure. The treated group also evaluated their quality of life as much better than before the procedure, despite a few persistent side effects like gait disturbance and paresthesia — the sensation of prickling pins and needles.

Neurologist Dr. Bryan Ho, who is not involved in the trial, noted that tremor suppression remained sustained throughout the 12 months. But he expressed concern about the side effects of the treatment.

“Over a third of patients actually experienced either gait disturbance or paresthesia. It’s a pretty high incidence of side effects,” said Dr. Ho, who is the director of the Movement Disorders Program at Tufts Medical Center.

He added that since these patients were only followed for a year, there isn’t enough data available yet to determine the long-term efficacy of the treatment.

“It’s one and done,” he said. “Patients may have some benefit for a period of time, but how do they do five years from now or 10 years from now after the treatment? That needs to be shown.”

The researchers are in the process of collecting this data; the clinical trial will run until December. The doctors at Brigham will follow up with Samuels — and others who undergo the treatment — for up to five years and run more MRI scans and neurological exams to find out for how long the lesion lasts and keeps the tremor suppressed.

For now, the treatment has had an immense impact on patients’ lives. “These people are able to go back and now use that hand like you and I use our hands, without thinking about it,” said Dr. Cosgrove.

“They can write their names again, they can feed themselves, they are not embarrassed about being in public. So it really is extraordinarily helpful for people.”

  • Debbie, you can find a list of treatment centers on They have just recently come online in the USA. I don’t see one in Florida; I think the closest one us in Charlottesville, Virginia. Call 434-924-0451 to the UVA Health System.

  • Please…..Tell me where in Florida we could see a neurologist that does this procedure for my husband which has been diagnosed with Essential Tremors for five years now and pills are not helping him at all!! Please…..We are desperately trying to find an answer for this so please write us back? Thank you.

    • Debbie,
      We live in Florida as well and my husband has been diagnosed with ET. There is a location in Delray that does this procedure. It is called Sperling Medical Group. The unfortunate thing though is that they are not signed up with many insurances. They want you to pay upfront before the procedure then find out later what your insurance company would be willing to cover. That isn’t the correct way to do it. I have been inquiring with Florida Blue about getting out of state coverage. I don’t understand why Sperling doesn’t become “in network” with Florida Blue.

      As of Feburary 2nd, 2019 This facility will be in national network and will be covered by Florida Blue. (From what I have read)

      Hope this info helps.

  • I am UK citizen
    Suffers with essential Tremors uncle to write or eat
    Had medical treatment for many years under UK Neurologist
    Been advised surgical DBS
    But I am interested in Ultrasound DBS
    Prepared to travel to US
    Kindly suggest also the cost

    • My husband just underwent FUS for ET dominant Parkinsons in Haifa, Israel where the technology was invented. Rambam medical center in Haifa has the most experience and the cost was about $30,000 in US dollars. More importantly, it was a big success, stopping the tremor in his left hand, left foot and improved mouth tremor. You might want to check out Rambam web site and Insightec web site (company that developed) which lists the locations of all treatment centers. Go for it!

  • I have been following your progress on E T it’s very encouring I an other members of my family have E T

  • My tremor is in my dominate right hand and has gotten progressively worse over the past 10 years. I am 70 years old and the medication that I have been taking has little effect. I have my initial appointment with Dr. Elias at the Univ. of Virginia in Sept. and will look forward to the procedure as soon as it can be scheduled. Shaving, brushing teeth, eating, drinking, clipping nails, combing hair and many more simple everyday chores are difficult if not impossible. I was not looking forward to many years of more decline in daily functions.

  • My tremor is head and left hand and is pretty well controlled with a small dose of Endersl/Xanax. I am 75 and have been aware of a trmor since my mid 20’s. I see Dr. Mark Stacy at Duke Movement Disorders Clinic once a year. My question is: Is there any advantage to early treatment of ET before it increases?

  • For more information on essential tremor including trestment options, support groups, and a listing of movement disorder specialists around the country visit the International Essential Tremor Foundation at

  • I am 73 years old. I started getting essential tremor 4 years ago. My tremor
    is not in my hands but my speech. It is frustrating talking to people . Is there
    any way this procedure can help my speech?

    • Dave,
      I had FUS at UVA on June 8th with Dr. Jeff Elias. My tremor was almost completely reduced in my dominant hand to the point I can do everything a normal person can do again. I also suffered from voice tremor for many years where my voice was weak and cracked often like a teenager going thru puberty. Dr. Elias offeared no guarantee of relief as he said it is “hi or miss” as far as beneficial to voice tremor. Fortunately for me, my voice although not perfect is much stronger and no longer cracks and sounds so awful to be embarrassing. Just remember there is no guarantee of this result.
      Jack Plant

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