Wayne Eskridge knew he was carrying a few extra pounds, but he still considered himself a pretty healthy guy. When the then-68-year-old electrical engineer underwent gallbladder surgery in 2010, though, his surgeon noticed that Eskridge’s liver didn’t look quite right.

That spurred blood tests — it turned out his liver numbers were a little high — and then a referral to a liver specialist and two biopsies. The diagnosis felt like a death sentence: He had cirrhosis. His liver had become shrunken, knobby, and scarred, and would never heal; ultimately, the only treatment would be a liver transplant.

“It was a shock,” said Eskridge, who lives in Boise, Idaho. “I was dumbfounded. I’d had no clue.”


Eskridge felt fine, and he didn’t drink alcohol or have hepatitis C like many people with liver disease. Instead, the cause was non-alcoholic steatohepatitis, or NASH, which is what leads to cirrhosis in one-quarter of people with the condition. It is increasingly common, for reasons that are unclear, and there is no known cure.

Eskridge isn’t alone — people with NASH usually have no symptoms. It’s estimated that roughly 2 percent to 5 percent of adults in the United States have the disease, and that another 10 percent to 20 percent may have its milder cousin, non-alcoholic fatty liver disease, or NAFLD, according to the National Institute for Diabetes and Digestive and Kidney Diseases. NASH is expected to become the most frequent reason for liver transplants by 2020.

“We don’t have a complete understanding as to why some people develop NASH, so it’s been very hard to tackle,” said Rohit Loomba, a spokesperson for the American Liver Foundation and a hepatologist at the University of California, San Diego.

And without treatments, Loomba said, “patients feel demoralized because they are not able to effectively control their disease even though they know liver damage is occurring.”

Patients with NASH have high levels of inflammation in the liver, which boosts the risk of cirrhosis. The cause is unknown, although being overweight, having high cholesterol, and having diabetes all raise an individual’s risk of developing NASH.

The lack of a clear cause — and the absence of treatments — makes it incredibly difficult for patients to find reliable information about NASH despite the disease’s prevalence.

“It’s hard for the average patient to get good information,” Eskridge said. “There is so much information on the internet that leads people into doing things that are really not good for them. Things like liver cleanses — they suck people in, preying on the terror they feel.”

Wayne Eskridge
Eskridge is developing a website to help fill the information gap for patients diagnosed with NASH. Kyle Green for STAT

It’s frustratingly difficult to detect NASH. A biopsy makes the diagnosis, but most patients don’t seem sick, so there are usually few clues that they need this test. There are no blood tests specific for the disease, and changes in the liver don’t show up on imaging tests until the liver begins to become partially scarred — or fibrotic.

“A patient with early disease, like NASH, but without much fibrosis, might get missed,” said Michelle Lai, a hepatologist a Beth Israel Deaconess Hospital in Boston. Yet the best time to intervene is before someone develops extensive scarring, she said.

Even with a diagnosis, there is no drug treatment for NASH, although that may not be true for long, in light of a recent flurry of activity in the pharmaceutical industry. A number of major pharmaceutical companies have acquired smaller ones working on treatments for the disease.

In late September, Allergan bought Akarna Therapeutics and Tobira Therapeutics for $50 million and up to $1.7 billion, respectively. And last spring, Gilead acquired a NASH drug being developed by Nimbus Therapeutics in a $1.2 billion deal.

Treatments coming down the pipeline attack the disease process from a number of angles, from attacking fat deposits in the liver to battling inflammation to preventing — and even reversing — the scarring that occurs over time.

Among the most promising is obeticholic acid, which may slow or improve scarring in the liver and was developed by Intercept Pharmaceuticals; it is being tested to treat NASH and has already been approved by the Food and Drug Administration to treat an autoimmune liver disease called primary biliary cholangitis (formerly known as primary biliary cirrhosis). Other medicines in development include the drug originally developed by Tobira called cenicriviroc, along with Gilead’s simtizumab, which may combat scarring in the liver and elsewhere, such as in certain lung diseases.

Experts think NASH may arise through different mechanisms in different people, so as in many conditions, some patients may respond better to one type of medicine than to another.

“There’s a ton of activity now in pharmaceuticals [to fight NASH], which is good, because this is a huge heterogeneous disease population,” said Mark Pruzanski, CEO and president of Intercept Pharmaceuticals. “No single company can do this alone.”


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Treatments for NASH are about where medicines to treat hepatitis C were a decade ago, Pruzanski told STAT.

“Just think about the huge growth in awareness and the tremendous innovation that led to a pill that cures hepatitis C,” Pruzanski said. “That’s ultimately the goal with NASH.”

So why the sudden interest in treatments for the disease? Some stems from increased awareness among patients and doctors, along with a growing number of people with NASH and risk factors for the disease.

Also, until recently, researchers had focused on treatments for other liver conditions, such as hepatitis C, that are more easily diagnosed and progress more quickly to irreversible liver disease, Loomba said.

Another reason is that until very recently, the way the benefits of treatment ought to be measured in NASH drug trials was unclear, so most drug companies shied away from it. Quite simply, no one had really tried to treat it before Pruzanski founded Intercept in the early 2000s, he said.

“There was no regulatory path to approval,” he said. “People were reluctant to commit early, and as a result there was very little activity until recently.”

Interest in NASH treatments is good news for Eskridge and other patients. A recent biopsy showed that his liver is free from inflammation, thanks to a 40-pound weight loss, dietary changes, and a more active lifestyle. But he can’t reverse the damage that likely started decades before his diagnosis. And Eskridge is the first to admit how difficult it can be for many people to drop the extra pounds.

“As a society, we don’t really convince people that weight loss is important; we talk about fat as more of a cosmetic thing,” Eskridge said. “Most people don’t really understand the biochemical dynamic of the fat in the liver and the damage that occurs as a result.”

Lifestyle changes and weight loss will still be crucial even if there’s eventually a drug that can treat NASH, liver specialists emphasize. That’s because NASH indicates a high risk of other health dangers that a liver-disease pill wouldn’t treat, such as high cholesterol and heart disease.

“Patients with NASH have a higher cardiovascular mortality risk — it’s a marker of being at risk of other diseases” such as diabetes, said Lai. “NASH patients die more often of heart attacks than of end-stage liver disease.”

Eskridge is devoted to spreading the word about the disease. He frequents Inspire, an online patient community, where he answers questions about NASH, and is even developing a website of his own that he hopes will serve as a resource for those who have been diagnosed.

“The level of fear that people have, and the lack of knowledge, is just palpable,” said Eskridge.

Today, although the only treatment for NASH remains lifestyle changes, Eskridge is doing all he can. He’s hopeful he will live many more years.

“When I got the diagnosis, it was a difficult time,” Eskridge said. “But I feel very confident about the path that I’m on.”

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  • I was just diagnosed this winter. First I was told there was nothing could be done for my liver, it was dead. Then I was told a transplant would likely be the only hope. Then I was told I was not a suitable candidate for transplant, as I have other comorbidities that may or may not kill me, making them decide it would be a waste of a good liver if they gave it to me, and then I died anyway from a non-related disease. In fact, they made this decision themselves, without referring to the transplant committee who is charged with making these decisions. It has been a complete roller coaster, and I’m definitely not winning.
    I do so know what you mean about time of diagnosis being difficult. If there is a way, I would like to be put on a list to receive all of your blogs, it felt so nice to read about someone who understood what I’m going through. Thank you.

  • I have recently found out that I have NASH. I am trying to gather as much information that I can do that I can understand and help to go down the right path for wellness

  • I was just told that I have NASH today, never heard of this until today. I love your story Mr Eskridge and hopefully I could live a long time with this disease.

    • I have had weird off the wall symptoms for over 12 years. Always ending in scoping of both ends and then being told it’s just acid reflex or an ulcer. Finally in Boise a doctor recommended after a scoping last week a liver biopsy to find out why my numbers are high and I have fatty liver. I’m terrified but at the same time I would love some answers.

  • My sister has Hepatitis, apart of a kidney. She was given little time to live in 2006. She needs a kidney transplant. Is there anyway for her to volunteer in the transplant study of the kidney already with Hep C since she has that also. It would give her the option of overcoming both issues. Sincerely, Beth Cartwright P.S. Please contact me if possible

    • You seem a little confused Hepatitis is a liver disease that would not be treated by a kidney transplant. Your sister needs to see her doctor to explain things.
      I have cirrhosis the none alcoholic kind. I always start there one of the charge nurses on an orthopaedic ward treated me like dirt because she thought I was an alcoholic.
      I have also been told I can’t have a transplant because I have a host of other medical problems. But I am still here a little sick sometimes. I am 70 and was told I would die in 6 months when I was 65.

  • My brother(who does not drink) has been diagnosed with cirrhosis of the liver. His understanding was that a medicine he had been taking might have caused it. Years ago I was diagnosed with a fatty liver. Should I be asking my dr. to check blood tests for NASH?

  • Very interesting article. I was diagnosed with NASH, stage 4 fibrosis with a MELD score of 6 (which is very good). I also have gastric varices, portal hypertension and fundal polyps. I am overweight and need to lose around 80 pounds. I am on insulin three times per day and it is very hard to lose the weight. Thank you for keeping us informed. I wish you every good thoughts and prayers for your recovery.

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