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LYNN, Mass. — He didn’t notice the night sweats.

It was August, and he had no air conditioning, so it was normal for him to wake up with sweat-soaked sheets. Nor did Dr. Kelly Holland notice the weight loss.


But he noticed when he started coughing up blood clots. He knew there were two main possibilities: tuberculosis or lung cancer.

A CT scan revealed the trouble: a gaping black hole in his left lung. It was a little bigger than a golf ball. Holland and his wife hugged. It wasn’t lung cancer.

Then he walked to the nearest emergency room and told the staff he needed a mask and an isolation room.

Holland’s diagnosis with tuberculosis in 2014 wouldn’t be solved with a brief stint in the hospital. Like all cases of active TB, it would turn into a detective story — and a public health nightmare. Nurses would have to track everyone he could have infected — in his case, some 1,000 people, mostly his patients and their family members. They’d have to put dozens of babies and toddlers on powerful drugs that turned their bodily fluids orange. Holland himself would have to take 17 pills a day for months.


The experience exhausted him. But it also turned him into an activist at what could be a critical time for TB in the United States.

Kelly Holland lung scan
A CT scan of Dr. Kelly Holland’s chest shows a hole a little bigger than a golf ball in his left lung, seen here in the lower right. Courtesy Kelly Holland

For nearly 60 years, the number of active TB cases in the US has been generally moving downward. But in 2015, the Centers for Disease Control and Prevention reported 9,563 cases of TB. That’s 142 more than the year before. The disease has sparked panic in places like Marion, Ala., where public health officials desperate to stop the spread earlier this year began paying residents to take their medicine.

Globally, TB presents a bigger problem than anyone thought, according to a World Health Organization report released last week. Last year, 10.4 million people got sick with TB — nearly a million more than a United Nations estimate for 2014.

TB remains rare in the US: there are just three cases per 100,000 people. And the increase in 2015 is proportional to population growth. Still, experts are worried. The last time we saw such an uptick in the raw number of annual cases was in 1992, the worst year of a TB resurgence linked to big cuts in public health budgets and the spread of HIV, which destroys immune systems.

Each case of TB creates a monumental amount of work. Public health officials have to track down and test everyone who may have been exposed. They also have to monitor each patient to make sure they’re swallowing their daily handful of toxic pills. If the patients don’t complete treatment, the bacteria that cause TB could become drug-resistant.

But some experts worry that the public health infrastructure can no longer handle the caseload.

“You are right at the edge of the cliff,” said Peter Davidson, head of TB control for the state of Michigan and president-elect of the nonprofit National Tuberculosis Controllers Association. “You haven’t fallen off it yet, but you’re so close if somebody gives you a little push or there’s a slight gust of wind, you could fall over. Really bad things haven’t happened yet, but they may not be that far away.”

The solution, he said, is more funding: “In the US, we have really reached the point of maximum progress we can make against TB with the infrastructure and funding that we have.”

“Really bad things haven’t happened yet, but they may not be that far away.”

Peter Davidson, National Tuberculosis Controllers Association

To Holland, that isn’t just a public health issue. It’s a moral one.

TB is easy for politicians to ignore, he said, because it primarily affects the marginalized: refugees, the homeless, the imprisoned, the impoverished. That is part of the reason he thinks policy makers fail to adequately fund TB control. In Massachusetts, for example, when inflation is factored in, funding for the cluster of programs that includes TB control has dropped 25 percent since 2008.

Holland wants to use his story to reverse that trend. The disease is spread by tiny droplets released when a person coughs or laughs. That means that anyone could be at risk. All they have to do is breathe.

“If one does not feel it is a moral obligation [to fund TB control], well, sometimes policy makers do things out of fear,” he said. “If you don’t do it because it’s the right thing, do it out of your own damn interest.”

Kelly Holland Kenya
Holland treats a patient in Kenya for tuberculosis pericarditis, an infection of the sac around the heart, in 2011 Courtesy Kelly Holland

A familiar foe

Holland was no stranger to tuberculosis when he came down with the disease.

In 2004, as a med student at the University of Massachusetts Medical School, he’d been treated for latent infection, meaning he had TB inside his body, but it wasn’t spreading or causing symptoms because it was kept in check by his immune system.

Then, as a medical resident in 2011, he’d spent a month in Kijabe, Kenya — a rural highway-side town, which translates as “Place of the Wind.” He was astounded at the prevalence of TB.

“I saw people with tuberculosis arthritis in the joints, I saw tuberculosis pericarditis, which is TB around the heart. I saw tuberculosis peritonitis, or TB of the intestine, and tuberculosis meningitis, TB of the spine, as well as TB of the lungs,” he said. “There wasn’t any presentation where we could eliminate TB as a possible cause.”

TB had even played a role in Holland’s engagement to his wife. He hadn’t wanted to spend money on a diamond mined and sold to finance a distant warlord, so he donated the sum he would have spent on a ring to Partners in Health, the global organization cofounded by the world-renowned TB expert Dr. Paul Farmer. His wife-to-be received a letter from Farmer that said, “Kelly loves you very much. That’s the good news. The bad news is, no ring.”

Holland and his wife have blue bands tattooed onto their fingers instead.

Holland was also well aware that the place he worked — Lynn, a working-class community north of Boston with a heavy immigrant population — had a lot of people with latent TB infections who often didn’t finish treatment. One of his colleagues at the Lynn Community Health Center had just started a unique program to treat these patients at the center where they get primary care, instead of sending them to a state TB clinic.

Despite all that, Holland didn’t think of TB when he woke up at 2 a.m. with severe chest pain in May 2014. In a feverish haze, he dragged himself along the Charles River to Massachusetts General Hospital. His chest X-ray came back a ghostly white. “Classic pneumonia,” he said. What the X-ray didn’t show — and what nobody thought to test for — was the TB hiding under all that white.

That’s a common oversight.

“More than 50 percent of our cases go to ERs around the state and get sent home with antibiotics, being treated for pneumonia or a cold again and again and again,” said Dr. John Bernardo, tuberculosis control officer for the Massachusetts Department of Public Health and a professor at the Boston University School of Medicine.

Holland was sent home with antibiotics, and soon he was back in the clinic, examining everyone from newborns to 98-year-olds. He didn’t know that he was harboring an infection that he might have acquired as far away as Kenya — or as close as the examining room next door.

Panic in an immigrant community

Three months later, Holland found himself walking the familiar path along the river to Mass General once again.

He’d just been diagnosed with TB and was heading for an isolation room at the hospital. This time, he knew that his lungs were full of potentially deadly bacteria. He knew that it might be spewing into the air with every cough. The chances of him infecting a passerby out in the open air were tiny — but still, he held his breath at every cyclist, every walker. “A symbolic gesture to myself,” he explained.

The people he was really worried about were his wife and toddler, his colleagues and his patients, all of whom had been in small, enclosed spaces with him.

But there was nothing he could do. At the hospital, he was put into a negative pressure room, which whisked air into vents so that none of Holland’s germs could escape.

“The room was 16 paces by 22 paces, and I was in there for 11 days,” he said.

His friends sent him books about famous prison breaks. But he was too sick to read. He slept 18 hours a day, lost 20 pounds, and chatted with the only people who were allowed to enter: doctors, nurses, and custodians in N-95 respirator masks, which keep out particles larger than 0.3 microns.

Meanwhile, there was panic in Lynn.

“People freaked out,” said Joyce Reen, director of nursing at the Lynn Community Health Center. “You could have been telling them there was an Ebola outbreak, or a typhoid outbreak, or an anthrax outbreak. They equate TB with all that.”

Their fear was understandable. Lynn is full of immigrants from Sudan, Eritrea, Afghanistan, Iraq, and all over Latin America. They knew about TB from their home countries: They knew it was a disease that could get you sent away to a distant hospital. They knew it could cause you to waste away in isolation.

“They don’t want to know they have TB, and they don’t want other people to know. There’s a stigma,” said Dr. Hanna Haptu, who started the TB treatment program at the Lynn Community Health Center.

Dr. Hanna Haptu
Dr. Hanna Haptu, right, discussing TB infection with a patient who was diagnosed with latent tuberculosis two months ago. He visits the clinic in Lynn monthly. Kayana Szymczak for STAT

Many also feared getting swept up by authorities. After all, the state government tracks all cases of active TB, and patients who don’t cooperate with treatment can be forcibly confined to a hospital.

“A lot of our patients are undocumented, and when they hear you want to screen them or screen them again, they’re afraid you want to turn them over to Immigration and Custom Enforcement and they’re going to get deported,” explained Reen.

To reach the 1,023 people who could have been exposed to Holland, the team sent out letters. When they didn’t hear back, they sent them out again, this time by registered mail. They did television interviews and newspaper interviews, and even sent outreach workers to knock on doors.

Their message, Reen said, was clear: “You must come in and let us help you.”

They reached hundreds. They had to test each person twice — once as soon as possible, and once two months later, in case the first test had been a false negative.

For kids under 5 whose immune systems are still underdeveloped, that window can be a death sentence, often allowing TB to infect their brain or spine. So any toddler or infant who had had contact with Holland within the previous three months was put on TB meds, just in case.

That included Holland’s own 2-year-old. Holland had to slather the pills in peanut butter to trick his son into swallowing them. “Watching [him] take the medication turned my stomach in a knot,” Holland says. He has pictures from that time. In one, his son’s face is bloated from crying, his nose dripping snot the color of Orange Crush.

As it turned out, the risk was quite low: Because the cavity was so deep in Holland’s lungs, he wasn’t coughing out as much bacteria as he might have been. Both his toddler and wife ended up testing negative — and so the chances he had passed the bacteria to anyone else were slim.

Yet Holland kept thinking about the trouble his diagnosis had caused. The panic among Lynn’s refugee population, already so mistrustful of medical authority. The woman who nearly went into acute liver failure because of the TB meds she had to take. The infants whose diapers were full of orange diarrhea.

All of that had been handled by a kind of medical SWAT team composed of public health nurses from Boston and Lynn, outreach workers from the state, and the group at the Lynn Community Health Center.

But other communities don’t have as many resources.

One example is Malden, a nearby town of about 60,000.

“It’s always something,” Maria Tamagna, Malden’s public health nurse, said this summer. “Today, it’s that one of my [TB] patients is lost. She’s not going to her appointments. I can’t find her. … It’s just impossible to keep on top of everybody every day.”

Tamagna also does myriad other jobs, including vaccinating children and teaching local officials how to reverse opioid overdoses. “TB is not my only problem in Malden, and yet it seems to be the thing that takes up most of my time,” she said. “It’s just so involved.”

That’s a familiar refrain.

“I guarantee you if you went to Iowa, or the Dakotas, or even California — let’s face it, they’re broke too — you’re going to hear the same thing,” Davidson said. “Any public health department is teetering on the brink of not being able to handle whatever is coming.”

Lynn TB
An educational booklet about tuberculosis at the Lynn Community Health Center. Kayana Szymczak for STAT

An activist is born

Seven months into his treatment, Holland showed up at the Massachusetts State House. He had even put on a tie, and traded the ragged hiking boots he wears in clinic for sleek black dress shoes. It was March 24th, 2015 — World TB Day.

“I’m not necessarily the right person to be here talking to you,” he told the legislators. “I’m an educated white kid from Western Massachusetts.”

Yet he knew that those most affected by TB — the incarcerated, the malnourished, the homeless, the displaced — probably wouldn’t get invited to speak under the golden dome of the State House.

“I throw on the white coat, people tend to listen,” Holland later said.

At first, Holland was reluctant to team up with the advocacy group Stop TB Massachusetts, which organizes weekly visits to press lawmakers for more funding and education. He thinks of “lobbying” as a dirty word. His fellow activists soon helped him get over it.

“It can actually be about educating people’s decisions,” he said, “not just about providing shady briefcases full of hundred dollar bills.”

Longtime activists said Holland’s presence — and his moving personal story — had an impact.

“The air felt different when he was talking,” said Cynthia Tschampl, a TB researcher at Brandeis who helps organize the advocacy visits. “He energized those of us who have been doing this for a while.”

Holland wants to raise awareness. If more doctors think to test for TB, fewer people will be sent home, as he was, with a simple pneumonia diagnosis. They’ll get the proper treatment sooner, and that will reduce the chance of TB spreading.

He’s also asking for more funding. An estimated 13 million people in the US have latent TB. About 10 percent of those will at some point develop the active infection. That’s a lot of monitoring.

A few of the legislators Holland spoke to voted to increase funding for TB control in the state’s 2017 budget. It didn’t pass. But Holland plans to keep trying. “Everybody,” he says, “deserves to have a treatable disease treated and a preventable disease prevented.”

  • Since Dr Holland’s work would have put him in a high risk category for TB, was he being tested using the quantiferon gold test? Or was he just not tested because he had been diagnosed and treated for latent TB and PPD testing was considered not to be useful? Is there a test that can track TB in someone already treated for it?

  • Kelly, You are one remarkable young man….. nothing in the article surprised me, it is you through and through……right down to putting on the tie and black dress shoes to plead you case for the poor…… I am sure you know the song…..God has chosen me, God has chosen me. It is so!!! I am so proud of you and your beautiful wife and I know your Mom and Dad, brother and sister are saying “That’s our Kelly. So glad you are well again. You are in my prayers as well as your family and close associates and all you treated. Much love and a big hug!

  • Kelly is a wonderful caring doctor whose mission is most important to world health. God bless you, Dr. Holland and keep up your courageous fight to help others – something you do so well.

  • Remember my mother telling when she arrived in US via Ellis Island from Scotland, everyone was tested for T B and other diseases and were not allowed in until they were treated. What a concept. Now we don’t even know who’s here.

    • Contrary to Trump hysterics, we definitely DO know who’s here. We just have not taken this disease seriously. Most think of it as a disease from a century ago. The current president’s fear of vaccines is not helpful.

  • Excellent article and realistic portrayal of the personal and public health concerns when someone is diagnosed with TB. We need more people willing to come forward and educate. Thanks.

  • Great Job Eric! You captured the situation and presented it in format that was touching, humorous, and educational. Also this week is “National Infection Prevention Week” so, great timing as well. Thank you! Deb

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