If you think the dismaying failure of hundreds of experimental drugs for Alzheimer’s disease is kick-starting efforts to find very different approaches — flickering LEDs, anyone? — you’re right. Or half right. The 100-plus studies at this week’s 9th Annual International Conference on Clinical Trials for Alzheimer’s Disease (CTAD) in San Diego all reflect work that began years ago, but with the conventional strategies of removing amyloid or tau from patients’ brains going down in flames, novel ideas are getting a more serious look.

Several companies are zeroing in on the essence of Alzheimer’s: not amyloid plaques at the synapses between neurons, not tau tangles within neurons, but the destruction of synapses and the death of neurons, which are the fundamental causes of dementia.

Unlock this article by subscribing to STAT Plus. To get you started, enjoy 50% off your first 3 months!

GET STARTED

What is it?

STAT Plus is STAT's premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond.

What's included?

  • Daily reporting and analysis
  • The most comprehensive industry coverage from a powerhouse team of reporters
  • Subscriber-only newsletters
  • Daily newsletters to brief you on the most important industry news of the day
  • Online intelligence briefings
  • Frequent opportunities to engage with veteran beat reporters and industry experts
  • Exclusive industry events
  • Premium access to subscriber-only networking events around the country
  • The best reporters in the industry
  • The most trusted and well-connected newsroom in the health care industry
  • And much more
  • Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr.

Leave a Comment

Please enter your name.
Please enter a comment.

Your daily dose of news in health and medicine

Privacy Policy