W

hen you think of CRISPR, the suffix “Cas9” seems immediately to spring to mind. But the Cas9 enzyme isn’t the only endonuclease that could be used therapeutically, according to North Carolina-based Locus Biosciences.

The startup is exploring the use of CRISPR/Cas3 in developing a new line of drugs that kill bacteria and fungi. If Cas9 works like scissors in gene editing, Cas3 is like Pac-Man — it just eats away at DNA. And it looks like it’s got its own unique set of applications. STAT chatted with Locus CEO Paul Garofolo, as well as cofounder Rodolphe Barrangou, who discovered this technology:

This is a STAT Plus article and you can unlock it by subscribing to STAT Plus today. It's easy! Your first 30 days are free and if you don't enjoy your subscription you can cancel any time.
Already a subscriber? Log in here.

Leave a Comment

Please enter your name.
Please enter a comment.

Sign up for our Morning Rounds newsletter

Your daily dose of news in health and medicine.