Dr. Tom Frieden arrived on the Atlanta campus of the Centers for Disease Control and Prevention to take on the job of CDC director on June 8, 2009 — three days before the World Health Organization declared the first flu pandemic in 41 years, caused by the H1N1 virus. That into-the-deep-end start set the stage for the next seven and a half years.

Frieden, who had been New York City health commissioner, steps down on Friday at noon EST. During his tenure, the country’s premier public health institution faced back-to-back-to-back health crises. The largest ever Ebola outbreak. A multi-state outbreak of fungal meningitis, triggered by contaminated steroid products made by the New England Compounding Center in Framingham, Mass. The Zika epidemic in the Americas.

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