It’s been a perplexing puzzle in the flu vaccine world — what’s going on with FluMist?

The Advisory Committee on Immunization Practices said last June that the live-attenuated vaccine, made by MedImmune (a division of AstraZeneca) should not be used this flu season because some US studies from three recent years suggested it offered poor or no protection in children aged 2 to 17.

Unlock this article by subscribing to STAT Plus and enjoy your first 30 days free!


What is it?

STAT Plus is a premium subscription that delivers daily market-moving biopharma coverage and in-depth science reporting from a team with decades of industry experience.

What's included?

  • Authoritative biopharma coverage and analysis, interviews with industry pioneers, policy analysis, and first looks at cutting edge laboratories and early stage research
  • Subscriber-only networking events and panel discussions across the country
  • Monthly subscriber-only live chats with our reporters and experts in the field
  • Discounted tickets to industry events and early-bird access to industry reports

Leave a Comment

Please enter your name.
Please enter a comment.

  • The easy answer would be rapidly mutating viral strains, or maybe Americans put too much other stuff up their noses. The problem has also probably led to some corporate agita as well. Reminds me when I worked for Lorex Pharmaceuticals, a JV between GD Searle and Synthelabo (now Sanofi). We were phase 3 of an international development program for what would have been the first non benzodiazepine anxiolytic. As the US monitor I was responsible for reviewed the lab results as they came across the printer. There was an unmistakable trend, with about 15% of the study subjects having significantly elevated liver enzymes along with pretty weak efficacy. When we informed our French JV partners who originally developed the drug they said “how come our drugs don’t work in America”. Ironically our next joint project was development of Ambien, which turned out to be, and still is a very popular drug. Development of the anxiolytic was eventually stopped due to the liver function problem.

Sign up for our Daily Recap newsletter

A roundup of STAT’s top stories of the day in science and medicine

Privacy Policy