eter Larsen watched a discouraging cycle of pharmaceutical companies touting a new treatment for Alzheimer’s only to be followed by a failed drug trial. So he considered another approach.

The Duke University biologist, who studies mouse lemurs that have symptoms resembling Alzheimer’s, co-authored a paper with a Duke neurologist that considers whether the science behind failed Alzheimer’s drugs incorrectly equated the buildup of amyloid plaques — a waxy protein inside the brain — with a cause of the memory-destroying disease rather than a symptom. Called the “amyloid hypothesis,” this line of thinking has been called into question with the recent failures of drugs targeting amyloid.

This is a STAT Plus article and is only available to STAT Plus subscribers.
To read the full story, subscribe to STAT Plus or log in to your account.
Good news: your first 30 days are on us.

Leave a Comment

Please enter your name.
Please enter a comment.

Sign up for our Morning Rounds newsletter

Your daily dose of news in health and medicine