s a district sales manager for Insys Therapeutics, Jeffrey Pearlman led a team that aggressively pushed doctors to widely prescribe the company’s highly addictive opioid painkiller Subsys. He even threatened to stop paying a nurse speaking fees if she didn’t help boost sales of the drug, emails show.

All the while, Pearlman held a secret: He himself was addicted to opioids like the very ones he was promoting.

Pearlman’s daily regimen of painkillers included the highest doses of his company’s own product. In extraordinary court filings, he details a miserable — and increasingly fruitless — odyssey to get pain relief from these opioids following a debilitating car accident. The pain subsided only when he stopped using opioids and turned to marijuana.


Subsys is a prescription form of fentanyl, and the risk of addiction is so strong that it is regulated by a special program at the Food and Drug Administration. The drug can cost tens of thousands of dollars a year, and Insys was subsidizing the cost of Subsys for Pearlman until the company fired him in late 2015, according to court filings.

Pearlman was also taking OxyContin three times a day and multiple Percocets daily. All of the drugs were legally prescribed, according to Pearlman.

“What happened with this guy, while his situation is interesting and ironic, is no different than millions of others who have gotten into deep trouble because of tolerance and increasing doses and false teachings about opioids from the early 1990s,” said Dr. Gary Franklin, a University of Washington researcher who has studied long-term use of opioids for conditions like back pain.

Pearlman was indicted in February for allegedly participating in an illegal campaign to convince doctors to prescribe Subsys, including for patients who don’t suffer the severe “breakthrough” cancer pain that the drug was approved to treat.

Documents in the case reveal that Pearlman recently began using marijuana, which he describes as a far cheaper and more effective treatment for his pain.

Marijuana Card redacted
Jeffrey Pearlman’s medical marijuana card. His home address and patient identification number were obscured by STAT.  Marijuana Card

While he has a medical marijuana card from the state of New Jersey, his ability to continue using the drug is threatened by the requirements of his bail. Many states have legalized medical marijuana, but the drug remains illegal under federal law. Pearlman has filed a motion in US District Court in New Haven, Conn., to remove drug testing as a condition of his bail so that he can continue using marijuana.

“If Mr. Pearlman is now denied access to medical marijuana treatments while on bail, he would likely be forced to revert to the use of these opioids again — and face the renewed threat of addiction as well as harmful side effects,” according to the motion filed by his lawyers in federal court.

A decision on his request is pending. In the meantime, Pearlman has been drug tested and continues to use marijuana.

A spokeswoman for the Administrative Office of the U.S. Courts said the agency couldn’t comment on specific cases. However, the courts have advised federal probation chiefs that “even when states have legalized marijuana possession for compassionate medical use, the federal prohibitions against possession, use, and distribution remain in effect.”

Pearlman declined to be interviewed for this story. Insys did not respond to a request for comment.

Opioid use began after car accident

A car accident more than 20 years ago left Pearlman with a severe injury to his spine that still causes him severe and chronic back and leg pain, according to the court records. In addition to opioids, Pearlman has tried steroid injections and other procedures to help with his pain, but they provided only temporary relief.

Pearlman reported that opioids impaired his mental function, making him “foggy” at times, and that he had difficulty remembering events, people, and other details. The drugs also caused psychological side effects, making him anxious and depressed. He also suffered physical symptoms, including a racing heart, inability to sleep, and gastrointestinal distress. To help with those side effects, Pearlman said he took daily doses of Xanax for anxiety and Ambien to help him sleep, as well as six different drugs for mental health issues allegedly caused by the opioids.

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Last summer, Pearlman went through an excruciating, monthlong detoxification from opioids.

“The path to break his addiction was painful, both physically and psychologically,” Pearlman’s lawyers wrote in a court filing. “Mr. Pearlman barely slept for a month, had constant nausea and the shakes, experienced extremely high anxiety, felt like his skin was crawling, and sweated profusely throughout the period.”

Pearlman was successfully weaned off opioids and antidepressants.

“Since stopping opioids and starting medical marijuana, Mr. Pearlman has had a great reduction in pain, without the harmful side effects associated with opioids,” according to a court filing.

To not allow him access to marijuana while the charges against him are pending could force Pearlman to choose between turning again to the addictive opioids or living with “debilitating pain,” a scenario his lawyers contend would be both “horrendous” and “inhumane.”  They also argue such a situation would impair his constitutional right to participate in his own defense.

He has pleaded not guilty to one count of participating in a kickback scheme to get health care practitioners to prescribe Subsys.

The indictment alleges Pearlman oversaw an illegal and successful effort to get an advanced practice nurse in Connecticut to write more prescriptions of Subsys.  To induce the nurse to prescribe more, Pearlman was part of an alleged conspiracy that paid her $83,500 to participate in a sham “speaker program.”

Pearlman was allegedly present at one speaking event featuring the nurse in which sign-in sheets were forged with the names of people who did not attend.

At many of the events where the nurse was featured as a speaker, the only attendees were friends of the nurse and office staff, according to the indictment. In other cases, the only people present were the nurse and an Insys sales representative.

Pearlman, in emails, made it clear the purpose of paying the nurse through the speaker program was to generate more prescriptions, according to the indictment. At one point, Pearlman expressed frustration with the nurse and threatened to yank her from the speakers program.

“Very simply when I look at return on investment as she has not motivated any new prescribers as of yet and she is not significantly increasing her own business, I am going to have tremendous difficulty in justifying more programs,” according to an email Pearlman allegedly sent to a sales representative. The nurse subsequently increased her prescribing and Pearlman later wrote to a superior that the nurse, after averaging about one prescription per week, wrote five in one day.

Pearlman joined Insys in 2012 and quickly rose to district sales manager, overseeing sales in Connecticut, New York, New Jersey, Massachusetts, and Rhode Island. He was fired in December 2015. Prior to joining Insys, the 49-year-old Pearlman sold home aquariums and operated a ticket brokerage business. He lives in a New Jersey suburb just outside New York City.

Marketing tactics under investigation

Insys faces a myriad of state and federal investigations into its sales practices.

In December, the former chief executive of Insys and several other former company officials were arrested on federal charges of conspiring to bribe doctors to prescribe Subsys. The officials have pleaded not guilty.

The indictment alleges doctors were enticed by various perks to prescribe the drug. In one case, a Florida doctor who was treated to “one of the best nights of his life” by Insys officials allegedly responded by increasing the number of Subsys prescriptions he ordered for patients

Two doctors, one nurse, and a former Insys sales representative have either pleaded guilty or been convicted of charges related to the illegal marketing and prescribing of Subsys.

Subsys is approved for the use of breakthrough pain in cancer patients. Federal and state investigators, however, allege the company has pushed the drug for so-called “off-label” use in chronic pain patients who don’t have cancer.

One patient prescribed Subsys for chronic pain — 32-year-old Sarah Fuller of New Jersey — fatally overdosed on the drug. The New Jersey attorney general subsequently launched a probe of high-prescribing Subsys doctors in that state and successfully moved to suspend the license of Fuller’s doctor.

Is marijuana an opioid alternative?

There is evidence marijuana-based products may be an effective alternative to prescription opioid painkillers. Research in the area has been stunted, in part, by the fact the Drug Enforcement Administration continues to classify marijuana as a Schedule I drug — the most restrictive category. Drugs in this category are deemed to have a high potential for abuse with no accepted medical use.

Two studies found a decline in opioid-related deaths in states where the use of medical marijuana is legal. One possible reason: Prescriptions for opioid pain relievers fell after medical marijuana was legalized, though the findings don’t prove the availability of medical marijuana caused this decline.

“There is now good evidence that medical cannabis is effective for treating some types of chronic pain,” said Dr. Daniel Clauw, the director of the Chronic Pain and Fatigue Research Center at the University of Michigan. “Cannabis is at least as effective for many pain conditions, and has fewer serious side effects.”

Clauw, who has served as a consultant for several pharmaceutical companies, said he is reluctant to recommend medical marijuana for patients under 25 because of a heightened risk of addiction.

In March, the New York Department of Public Health added chronic pain as a qualifying condition for medical marijuana.

The increasing number of indictments and investigations of Subsys marketing has clobbered the stock price of Insys, and Subsys sales have sharply declined.

The company is now betting much of its future on a new drug called Syndros. The drug is a synthetic cannabinoid, a class of drugs comprised of chemicals related to those found in the marijuana plant.

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  • off topic – but you can buy a years supply of fentanyl (aka heroin) on the street for $1500 and the dealers make a boatload of profit. The article says “The (fentanyl) drug can cost tens of thousands of dollars a year”. This is what is wrong with big Pharma, huge profits that balloon the cost of health care.

  • Stop demonizing pain medication. It is vital medicine for people who live with pain. Start by dropping the dishonest “opioids” which implies that a three-day course of Percocet is equivalent to heroin. Taking drugs just to get high is very dangerous, but a three or four day course of pain medication for a person suffering pain is good medicine. For people who live with chronic, excruciating pain, the medication is absolutely essential.

  • What is the difference between him & a street corner drug pusher??
    They go to hard time prisons & he asks for Federal waivers to continue his MJ!!

  • I don’t feel sorry for him. Just send him to jail pending trial, then he won’t be tempted by the big bad pain pills

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