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Key insight: PD-L1, a molecular target of cancer immunotherapy, is so closely tied to pain in animal experiments, scientists think it may mean the more pain is felt, the better the treatment is working.

Pain exists for a reason: It alerts us that something’s gone awry in our bodies. Now, a new study suggests that some cancers might block our ability to sense the pain that radiates from a tumor —allowing it to continue growing, surreptitiously.

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