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Former Apple CEO John Sculley, who had a famously hot-and-cold relationship with Apple founder Steve Jobs, says the next multibillion-dollar opportunity to change the world is in digital health care.

Sculley has surfaced as chief marketing officer at the Southborough, Mass., startup RxAdvance, a cloud-based software company where he is working with founder and CEO Ravi Ika to disrupt the giant industry of managing pharmacy benefits.

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