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When antidepressants called selective serotonin reuptake inhibitors, or SSRIs, burst onto the scene in the 1980s, they provided much-needed relief for millions suffering from mood disorders like depression. However, even as SSRIs have become one of the most commonly prescribed drugs in the world, the details of how they interact with the brain remain somewhat mysterious.

Recently a research team at The Rockefeller University made strides in unraveling the brain circuitry in mice that responds to SSRIs, and pinpointed the cells where the response starts, information that could be used to develop more-effective treatments. Their work was published in Neuron.

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