PORTLAND, Ore. — Dr. Vinay Prasad is a professional scold: He takes to Twitter each day to critique this cancer drug as ineffective, or blast that one as overpriced, or dismiss the clinical trial of another as completely irrelevant.

So it’s a bit of a surprise to catch him at the bedside of an elderly man with lymphoma, laughing gently with his patient as he inquires about his day — and painstakingly explains a potent drug’s unpleasant side effects.

Prasad’s empathic bedside manner — and generally affable mien — is at stark odds with his digital persona as a caustic crusader for the principle that solid scientific evidence, not hope or hype, should guide how we as a society spend $700 billion a year on health care.

Just 34, Prasad has become an influential voice in the medical community through his prolific, high-impact publishing, a steady stream of media cameos, and — of course — his vociferous Twitter presence. Among his main arguments: Drug costs have spiraled out of control. Conflicts of interest run amok in health care. We don’t have any idea how well new cancer drugs and diagnostics work, thanks to ill-designed clinical trials. And more than half of all practiced medicine is based on scant evidence — and possibly ineffectual.

Needless to say, such positions haven’t won him many close friends among pharma companies — or even among some fellow doctors. He doesn’t much care.

Anyone is fair game for his ire: Scientific journals have the “long term memory of a squirrel.” Medications are “insane and unsustainable.” Eminent researchers back “unproven and likely-to-be-useless” strategies. Meeting with drug sales reps is a “waste of time.” And Scott Gottlieb, the new Food and Drug Administration commissioner, won praise from Democrats only because “the alternative was a box of rotting fish.”

“He tends to be so cynical and nihilistic,” said Dr. Eric Topol, a cardiologist and geneticist at Scripps Research Institute in La Jolla, Calif. “I try to encourage him to see some of the optimism in medicine.”

While he takes issue with Prasad’s style, Topol is a fan overall. That’s a common reaction. Many doctors don’t like his tone, or disagree with some of his specific conclusions — but nonetheless laud him for rigorous research. Prasad, who talks nearly as fast as he works, has co-authored nearly 150 articles since 2011, many of them published in top medical journals. (And he still, somehow, finds time to sleep at least eight hours a night — and bikes to work daily.)

“I think he’s rare in the fact that he thinks about individual patients, but also thinks about society and the population as a whole,” said Dr. Daniel Goldstein, a cancer researcher at Rabin Medical College in Israel who has done research with Prasad.

“He tends to be so cynical and nihilistic. I try to encourage him to see some of the optimism in medicine.”

Dr. Eric Topol

Critics point out that although Prasad champions transparency, he has blocked some foes who challenge him on Twitter, effectively shutting off dialogue with them. He rails against conflicts of interest and has taken no money from pharma, but he has accepted a $2 million grant from a foundation with an agenda that aligns with his own, including promoting efforts to rethink drug pricing and physician billing models.

Prasad himself acknowledges that although he dismisses many new cancer drugs as nearly worthless — and way overpriced — he will, at times, prescribe them if his patients insist, even after he has explained his reservations. But by and large, he sticks by his credo — that the only drugs worth prescribing are those that have been rigorously validated in clinical trials.

“I get the sense that he really holds a grudge against the pharmaceutical industry,” said Yevgeniy Feyman, a fellow at the conservative Manhattan Institute.

Gregg Gonsalves, an associate professor of law at Yale University and co-director of the Global Health Justice Partnership, takes a different angle on Prasad: He has dubbed him a “swashbuckling crusader for medicine.”

“He’s the guy who says the emperor has no clothes,” Gonsalves said.

True, the topics Prasad writes about can be rather dry. He frequently bemoans the fact that when a clinical trial fails to meet its stated goals, the researchers root around to find alternative metrics that will let them declare success. This week, he was deep in the weeds of research costs, with a paper that concluded companies might spend $650 million to develop a drug that can ring up $1.6 billion in sales.

But with his quick wit, conversational tone (he has been known to exclaim “omg” on Twitter) — and, yes, his habit of flinging colorful insults — Prasad has a way of drawing the public eye to this most unsexy side of medicine. He has more than 9,000 followers on Twitter, which doesn’t make him a celebrity, but it’s not bad for a guy who throws around jargon like QALY (a metric of quality of life) and R-CHOP (a chemotherapy regimen) and earnestly dissects the validity of Kaplan-Meier curves (a statistical analysis used in clinical trials to project survival rates).

“You might catch more flies with honey, and sure — Vinay could be sweeter with his critiques,” Gonsalves said. “But I don’t think that’d get very much attention.”

Vinay K. Prasad
Prasad first made his mark with the book “Ending Medical Reversal,” which he co-wrote with Dr. Adam Cifu. Amanda Lucier for STAT

An accidental doctor

Prasad, who studied philosophy in college, credits his entrance into the medical field to his college roommate at Michigan State: He was taking the MCAT, so Prasad decided to try out the medical entrance exam out himself. “I don’t know if I would have signed up on my own volition,” Prasad said. Had his roommate pursued law, Prasad might have as well.

He hated the first two years of medical school at University of Chicago, which involve hours upon hours of basic science lectures. He even considered quitting: “I couldn’t stand the rote memorization of things that seemed so useless,” he said.

As for research, he said, “I avoided it at all costs.”

It wasn’t until Prasad’s third year of medical school, when he began rotating in hospitals and interacting with patients, that he began to take serious interest in medicine. He hails from a family full of engineers, so had few preconceptions about clinical practice.

And he soon began to notice that many routine medical procedures didn’t have any solid evidence to back them up.

During his rotation through the hospital’s cardiac critical care unit, for instance, he was taken aback by the widespread use of stents, which are inserted in blocked arteries to open them up. They work well, of course, in severe cases when arteries are completely blocked. But in people who have chronic, stable angina — that is, mild heart disease with some chest tightness — there’s no evidence whatsoever that stents improve survival rates. Yet 80 percent of stents are placed in patients who have this mild angina. It’s become a $15 billion industry.

“He’s the guy who says the emperor has no clothes.”

Gregg Gonsalves, law professor

And it’s not without risk: During that rotation, Prasad saw a patient who’d had a severe heart attack related to the stent, and another who’d developed brain damage from complications during the surgery.

“All interventions have complications, sure,” Prasad said. “But if there’s no benefit to a procedure — then what the heck are we doing?”

Such realizations led Prasad to co-write a book in 2015 with his medical school mentor, Dr. Adam Cifu, a general internist studying evidence-based medicine at the University of Chicago. The book, tantalizingly titled “Ending Medical Reversal,” focuses on cases of treatment flip-flopping — in which medical creed is disavowed after being subjected to randomized clinical trial.

“The more you see this, you can’t look away,” Prasad said. “Everywhere I look, it’s the same thing.”

Vinay K. Prasad
Prasad bikes to work at Oregon Health and Science University, where he spends most of his time doing research. Amanda Lucier for STAT

A knack for making enemies

Prasad began to make enemies early on: Radiologists aren’t happy that he deems routine mammography pointless. Urologists don’t like him, either, because he’s been deeply critical of the PSA diagnostic test for prostate cancer.

In both cases, Prasad is concerned that there are too many false positives, which can cause patients great psychological distress. Scouring the data, he also argues that too often, the tests turn up cancer that does not really need to be treated — but is taking a physical and financial toll on the patient and sometimes leaving lasting side effects, like erectile dysfunction for men who have prostate surgery.

Of course, screening also sometimes finds highly malignant cancers and saves lives — so many urologists and radiologists resent Prasad for crusading against the tests.

Prasad takes that fury as proof that many doctors are too concerned with making money to follow the evidence where it leads (radiologists, after all, earn their living from conducting tests like mammograms, and urologists make money doing prostate surgeries).

“It feels like in medicine, if we forget the history, we’re condemned to repeat the errors,” Prasad said. “But why do we repeat them? Well, it just so happens that lots of people benefit financially from committing those errors.”

“Why do we repeat [our errors]? Well, it just so happens that lots of people benefit financially from committing those errors.”

Dr. Vinay Prasad

His critics, however, say Prasad is putting too much weight on statistical tables, instead of listening to the real-world experience of real-life patients and physicians. They also dismiss him as a generalist who doesn’t really understand the specialty fields he so angrily attacks — and doesn’t try to.

“He never wanted to hear the other side,” said Dr. Ben Davies, a urologist at University of Pittsburgh who has clashed online with Prasad. “In general, there’s an absolutism to his voice, which grates a lot of researchers the wrong way.”

Dr. Tomasz Beer, a prostate cancer researcher at OHSU — and the man responsible for bringing Prasad up to Portland — has been called upon to defend some of his more controversial remarks: “I’ve gotten calls from people at respected institutions saying, ‘Why the hell did you hire this guy?’” Beer said. “My answer: We support academic freedom and he’s doing good work.”

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“When we recruited him, we weren’t sitting around saying we need an iconoclast-in-chief,” Beer said. “He was just a really fantastic talent.”

How fantastic? Beer reaches for an analogy that’s sure to raise eyebrows among Prasad’s critics, likening him to a misunderstood genius, ahead of his time: “Where does Leonardo da Vinci fit in the art scene of 15th century Venice?” he said. “But if you see Leo, you get working with him.”

For his part, Prasad delights in shaking things up.

Too often, he said, physicians tread cautiously so as to not anger their peers by taking strong stands, declining even to step in when other doctors “are saying things that are completely erroneous or unsupported.”

But the world is quickly changing, and the traditional channels of sharing scientific research have morphed. “In a way, medicine is being democratized,” Prasad said. Some blogs, he argued, “are way better than any journal editorial — they’re more thoughtful, and have better points.”

And then, of course, there’s Twitter.

Prasad frequently uses the medium to critique clinical trial design — and press for better studies that more accurately assess whether a drug really works.

In oncology, many trials don’t assess whether a drug helps a patient lives longer — just whether it buys her additional weeks or months before her tumors start to grow again. (That metric is known as “progression-free survival.”) That bothers Prasad.

“Our results show that most cancer drug approvals have not been shown to, or do not, improve clinically relevant endpoints,” he wrote in a research letter published in 2015 JAMA Internal Medicine, citing his review of five years of cancer drug approvals.

He also complains that too many trials aren’t gold-standard, random controlled studies that compare experimental drugs against the standard of care.

Dr. Vincent Rajkumar, an oncology professor at Mayo Clinic who has collaborated with Prasad and supports his work, nonetheless finds such critiques a bit unrealistic. For instance, he noted, in the case of treatments for life-threatening diseases, if we waited to see whether a new drug improved overall survival, important medications wouldn’t be approved for many years.

“And it’s extraordinarily hard to do a randomized controlled trial in the U.S.,” Rajkumar said. “If we just wait for that, it’s not going to happen.”

It’s not hard to critique a clinical trial’s design after the results are out, Rajkumar said. But between funding woes, patient recruitment challenges, and prolonged regulatory timelines, the finished trial — and the outcomes that are evaluated — often end up a far cry from the original intention.

“It’s easy to look at a trial and say, ‘how on earth did anyone approve this design?’” Rajkumar said. “By the time a trial’s complete, it doesn’t look anything like the principal investigator envisioned.”

Vinay K. Prasad
Notes tracking his projects dot the white board of Prasad’s office.

Training future skeptics

One of Prasad’s favorite parts of his gig at Oregon Health and Science University? Training the next generation of doctors to be skeptics.

He helps lead the school’s oncology fellowship program, assigning trainees to give 15-minute talks every time a new drug is approved by the FDA. The young physicians must convince the OHSU tumor board that the drug truly deserved regulatory sanction.

Most of the time, they can’t.

He has also hired a small cadre of research peons — that is, medical students and residents — to carry out his grunt work. Right now, for instance, they’re busy trawling Twitter in search of physicians who use social media to praise drugs without disclosing that they’ve been paid by pharma companies.

“When we recruited him, we weren’t sitting around saying we need an iconoclast-in-chief. He was just a really fantastic talent.”

Dr. Tomasz Beer

His job is structured so that he devotes most of his time to research, working in a simply decorated office — with his many diplomas (including a master’s in public health from Johns Hopkins) taking up much of the wall space. His research grunts work on computers in a small attached vestibule.

Roughly one day a week, Prasad pulls on his white coat and walks over to the university hospital, where he treats patients with leukemia and lymphoma.

That’s where he sees the human stories behind the black-and-white statistical tables he spends hours parsing in his research.

True to his principles, Prasad makes sure to offer his patients the treatments that have the most proven survival benefits.

But he does also tell them about other options. He’ll tell them, for instance, that a new therapy is gaining popularity — but then explain why he’s reluctant to prescribe it. One example: He’s not yet sold on combining immunotherapy drugs, though that is an increasingly hot field of study.

“I’m a bit of an evidence-based purist, but a big believer in shared decision-making with my patients,” Prasad said. “There are some things I feel strongly about, but in terms of my practice, I’m not some outlier. I’m way within the spectrum of how people practice oncology.”

He even enrolls some patients in clinical trials — if, of course, they meet his standards for proper research design.

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  • Why oh why was this Donald Trump wannabe profiled? As a physician actually doing the important work Vinay only whines about, I can tell you why he is so despised. And no, it’s not because he’s “outing” something about medicine. It’s because 100% of what he says is criticism of others – others doing far superior work – without offering any solutions himself. He is a faux researcher who just likes attention. Please stop giving it to him.

    • How dare Dr. Prasad question other doctors’ ethics as well as their willingness to make money doing unnecessary surgeries and prescribing drugs that do not work! That simply doesn’t happen because there are no doctors who could be guilty of such despicable behavior (snort, rolling my eyes).

      We need more doctors like Dr. Prasad who question the good ol’ boy network. Are you blind to the opioid crisis in America. Doctors who use social media to praise drugs without disclosing that they’ve been paid by pharma companies are despicable. These are the type of doctors who have a hand in this opioid crisis. They and big pharma, who care more about making money even when it destroys patients’ lives, need to be called out for what they have done and punished appropriately.

      You sir, with your holier than thou attitude, are part of the problem.

    • God forbid he should go against status and point out the glaring irregularities of health care. I’d like to think the doctor I go to for cancer treatment is in it for me and not big pharma. But that’s just me.

  • In every field there are a few who make a living out of finding faults in the field. Dr. Prasad is an example. If he really wants to help patients he should set up his own trial of a drug with his so called gold standards and statistics and publish his findings. Instead he’s made a livelihood out of whistle blowing in a field which is not absolute like Maths or even Physics. The most despicable point in the article was his misuse of undergraduate medical trainees to scour Twitter for messages where he can find a whistle to blow. He wouldn’t block the challengers if he applies his own so called gold standards to analyze his work.

    • Oh you poor dear. There’s a doctor who blows the whistle on bad behavior by other doctors. I guess you would also have the same distain for honest cops who blow the whistle on other cops who are on the take.

    • Why would he do that? It would take him away from the patients he’s trying desperately to save. Not all
      Doctors can be scientists, but I guess they don’t get to express an opinion because of it either.

  • I believe rather than a crusader , Dr Prasad should be stated as PostModernist and PostStructrualist . Working in a developing country as a Head and Neck surgeon , seeing such a high incidence of Òro Laryngeal Cancer, one does feel that cost and curation are two important aspects that influence the line of treatment. Yes there may be anecdotal as well as experimental proof about the success or failure of a treatment but before throwing away the baby with bath water, do we have a New Scientific way to challenge the Essentialism of so called Pharma Giants with rogue and crooked trials. Are all of them guilty ?? If it’s yes then there is a fundamental flaw in way we learn and practice medicine and if answer is no , then a regulatory and overbearing mechanism has to be developed. I do share the same sentiments on some of the issues as Dr Prasad but do everybody here believes that favouritism is seldom in Medical Line!!! Was Publishing so easy for everybody else ?? ( Ask any South East Asian Doctor ) . If one is relentless when experimenting on a guinea pig ( without its consent off course!!) why can’t a novel treatment be offered to a human on consent with all the ambiguosity explained in detail to him or her . Randomised Controlled trials are best, No doubt . But they establish Authenticity and not the Existence of a new treatment. Medicine is ever changing and ever building. One can rediscover, realise and retransmit it. There is no absolution here. As fraternity I think we should work on Global Platform with multicentric approach to make Medicine more inclusive, accessible and affordable.

  • Dr Prasad has published “150 articles since 2011, many of them published in top medical journals”. If you know anything about science, you will not believe that anyone can co-author even half of these 150 articles in just 6 years. This is 25 per year (over two per month). Perhaps this includes abstracts, are not peer-reviewed, there are ghost writers involved or just he belongs to a large group where everyone goes in all papers. As I said, I would not believe even half of that.

  • Wow! Dr. Prasad shares so much information to digest in this article. I think however, it is dangerously irresponsible for him to oust the results of clinical trials, medication effectiveness without taking into consideration that the practice of Medicine as a Science is NOT as clear cut as we would all like it to be. As in any field of study, in Medicine there is always room for improvements, revisions, and more effective research. To Dr. Prasad’s “enemies” I advise, meet with him and embrace his knowledge and enthusiasm to make MEDICINE better, rather than ousting him completely.

  • This is a bizarre puff piece. There are many clinical investigators that do their best to work with drug companies to design and run good clinical trials that benefit patients. You never hear about them, as they are too busy doing actual research and seeing patients – yet Prasad earns all the kudos with a stream of op eds and by screaming on twitter. It’s easy to be a crusader without the burden of actually having to do clinical research. Clinicians and researchers are well aware the system isn’t ideal and that clinical trials could be better. Prasad replays these truisms to the uninitiated (including Statnews) repackaged as shrill revelations. He doesn’t belong in the same sentence as Ioannidis (who provides reasoned statistical critiques) or Goldacre (who conducted valuable incestigative journalism).

    • “It’s easy to be a crusader without the burden of actually having to do clinical research”.
      Seeing certain other criticisms among these comments, I may re-think my high opinion of Prasad. But as a practicing physician, I think of myself as a consumer of biomedical research. Given Ioannidis results as well as his estimation of wrong results in published, am I wrong to prefer a better product for consumption? Some estimate as much as 20% greater likelihood of positive results with Pharma funding. Am I wrong to be concerned about proprietary raw data, p-mining, poor study design? Do I have time to review every possible paper that might affect my practice? No, I don’t. And I’ve seen my share of things that are widely employed for a time only to later be found to be of no value and occasionally actually harmful.

  • I have heard Dr. Prasad speak in person , on a panel with other docs, pharma execs. . I could see how he riled up the ” establishment ” mentality . I find him likable and the establishment certainly can use some shaking up . But, as a Stage IV pt. activist , I am concerned that he seems to push a return to the randomized , controlled trials of “old ‘ , i.e 20th Century . When we pt’. s hear the words ” randomized ” and ” controlled ” , we hear ” Small ” , and ” Slow ” . We think the 21st century drugs – starting with kadcyla, iclusig, lemtrada, perjeta – now keytruda, etc. benefit from more flexible , faster approval – 4- 5 yrs. vs. the old 20th century 7-10 yrs. Every yr. earlier can save hundreds , if not thousands of lives .

    • You invoke the false equivalence of new and better, similar to comparing natural and synthetic. Each case is different. So 21st century drugs are not necessarily better. By your logic, drugs that don’t even get to clinical trials in humans are better and will save lives.
      Unfortunately, the only way to prove safety, efficacy and superiority to existing treatment is with well-designed unbiased RCT’s. That truth holds in the 21st century. Despite so much hype for at least 40 years, medical science advances slowly. Many promising treatments are now being investigated. But history shows promising treatments are virtually always on the drawing board and the hope and hype associated with them pans out infrequently, in limited circumstances and/or after modifications based on further research or post-approval findings.
      What you propose is being a guinea pig and ensuring as many people as possible not only have that opportunity but are encouraged to do so. That attitude is financially irresponsible (pretty easy when it’s someone else’s money) but also irresponsible medicine. No one can predict the outcome of trials. But again history suggests overall minimal if any aggregate benefit, and equally possible harms. It is equally possible that every year earlier can cost hundreds, if not thousands of lives. I speculate you are looking for hope, perhaps even desperate. I honestly wish you the best. But while you may know some like-minded people, you are not a patient advocate.

  • Agree 100% with Susan Molchan on both points. Currently one of the louder voices, Dr Prasad joins the likes of Ben Goldacre and John Ioannidis and editors at Healthnewsreview.org in pursuit of better science supporting medical care.
    Unfortunately many subscribe to the very poorly reasoned justification of Dr Rajkumar. Inherent in that rationale is that he is willing to expose many patients to ineffective or even harmful regimens in hopes one unproven regimen actually benefits one patient.
    I wouldn’t characterize most physicians I work with as greedy, but no one is immune to financial incentives and no one wants a pay cut. Our current fee for service structure has too many wrong incentives built in. And the AMA’s RVS Update Committee has no reason to change that.
    Kudos to Dr Prasad!

    • Hurray for Dr. Prasad! Those who criticize him based on this article might want to read his absolutely constructive and persuasive book, which goes of course into far more depth about why there is so much medical reversal and what can be done about it.

  • Great to see Dr. Prasad’s important work highlighted–we need more truly evidence-based medicine. Makes up for recent STAT pharm-sponsored/ghost-written stumbles (now hopefully remedied by new op-ed policies)

  • We need more clinicians like Dr. Prasad. When did we all get so complacent when reviewing the evidence? Some of these oncologists (and cardiologists and neurologists, etc.) should be ashamed of themselves. Is it laziness or greed that dictates their standards of patient care?

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