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Flagship Pioneering, one of the leading backers of life sciences startups, said Wednesday that it has secured another $618 million in financial commitments from new and longtime investors.

The new venture round — Flagship’s largest one-time infusion ever — boosts to $2.3 billion the total capital raised by the Cambridge, Mass., firm since its founding in 2000. The money is used to start and fund biotech, medical technology, and bio-agriculture businesses.

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