When Julia Cheek walked onto the set of “Shark Tank,” her five potential investors wore their trademark scowls. Yet within minutes, their demeanor changed, eyebrows raised and heads nodding as they peppered her with questions about her company, EverlyWell, and its promise to revolutionize medical diagnostics.

“EverlyWell is transforming lab testing — a $25 billion market — to be simple, convenient, and useful for you,” she told the judges with a smile. Beside her sat a display of the company’s wares: mail-order test kits for everything from testosterone levels to sexually transmitted infections.

When Cheek left the stage, she had a fresh $1 million commitment from investor Lori Greiner. And the company is wowing more than just the television judges. EverlyWell garnered $6 million in sales last year, a spokeswoman said, and Cheek told the judges that this year they expected that to double.

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But what EverlyWell describes as one of its best-sellers — a test for food sensitivity — is of dubious medical value, according to experts interviewed by STAT. The $199 test promises to use a fingerprick’s worth of blood to gauge whether a person’s immune system is active against 96 common foods, including asparagus, garlic, and eggs. An immune protein called immunoglobulin G, the company’s website says, could be to blame for symptoms such headaches, stomach pain, diarrhea, and fatigue.

Other online vendors sell immunoglobulin G tests for food sensitivity as well, though none have reached EverlyWell’s degree of prominence. All are considered laboratory-developed tests, and are therefore not regulated by the Food and Drug Administration.

Yet physician groups have for years advised against using immunoglobulin G tests to evaluate for so-called food sensitivities or intolerances. And allergy experts told STAT that the test is useless at best and could even cause harm if it leads customers to unnecessarily cut nutritious foods from their diet.

“EverlyWell believes providing this test aligns with relevant third-party research around the [immunoglobulin G] test’s usefulness in conjunction with an elimination diet,” the company said in a statement.

To test or not to test

Food sensitivity is an umbrella term that encompasses symptoms that can arise, for example, from difficulty digesting a food, as in lactose intolerance, or susceptibility to the effect of a food, as in caffeine sensitivity. These symptoms, however, do not involve an immune response. (Food allergies, on the other hand, have more serious symptoms and are driven by the immune system; validated tests for them do exist.)

Patients who ask Dr. Robert Wood, an allergist at Johns Hopkins Children’s Center, whether they have a food sensitivity would never undergo an immunoglobulin G test. Immunoglobulin G tests “are completely useless and do dramatic harm” because they may compel patients to unnecessarily avoid broad swaths of a healthy diet, Wood said.

“In all my years of practice, I have never sent an immunoglobulin G test because they have no ability to predict food sensitivity,” he said.

That’s because immunoglobulin G stems from the body’s normal immune response to exposure to many substances, including food. High levels don’t indicate a problem; they simply point to foods a person recently has eaten.

For these reasons, a 2008 European Academy of Allergy and Clinical Immunology task force recommended against testing for a type of immunoglobulin G to evaluate for food intolerance. In the report, the group wrote that the test was “irrelevant for the laboratory work-up of food allergy or intolerance and should not be performed in case of food-related complaints.”

In 2010, a subgroup of the American Academy of Allergy, Asthma & Immunology, or AAAAI, endorsed this recommendation. And two years later, the Canadian Society of Allergy and Clinical Immunology too released a position statement discouraging the use of the test. The group noted that “positive test results … are to be expected in normal, healthy adults and children,” and that the test “increases the likelihood of false diagnoses … unnecessary dietary restrictions and decreased quality of life.”

A spokesperson for EverlyWell stated the company believes “there is a divergence of views regarding IgG tests,” and that the AAAAI does not speak for all health care providers. The company pointed to a handful of small studies that have showed immunoglobulin G helped guide elimination diets — that is, trials of cutting certain foods out of the diet and gauging symptom improvement.

“IgG tests are currently ordered by thousands of medical providers in the U.S.” the spokesperson said.

Dr. Martha Hartz, an allergist at Mayo Clinic in Rochester, Minn., says she frequently evaluates patients who’ve already forked over the cash for the testing. “Anytime I see a patient who’s had these kinds of tests, we get them to toss it aside,” Hartz said. “It has no relevance to anything. It is just not a test that should done.”

EverlyWell Food Sensitivity Test
EverlyWell’s food sensitivity test uses a blood sample to look for immune system activity. EverlyWell

Booming industry, shaky science

EverlyWell’s test is just one entry to the booming field of at-home testing. Alongside players in the genetic space, such as 23andMe and Color Genomics, upstarts are taking aim at standard medical testing.

EverlyWell and competitors such as Thorne allow customers to take a small blood sample at home to run a variety of tests. Others offer a narrower range of products: Habit, for instance, focuses on nutrition; Blueprint for Athletes caters to fitness enthusiasts.

But in the sheer scope of its vision the most obvious analogue to EverlyWell is blood-testing startup Theranos, which also aimed to upend the laboratory testing industry. At one point the company soared to a $9 billion valuation on its direct-to-consumer lab tests. But investigations revealed that its proprietary blood testing technology was deeply flawed, leading to a number of lawsuits; the company now is reportedly pivoting to medical devices.

No shortcut

EverlyWell’s food sensitivity tests exploit a frustrating fact for those wondering whether their symptoms stem from the food they eat: There is no easy way to find an answer. The doctor-advised approach is to cut common offenders from the diet one by one — a so-called elimination diet — but that is cumbersome, time-consuming, and, by its very nature, restrictive.

“It is hard to remove certain foods from the American diet, and people may want a definitive way to know which foods cause symptoms without eliminating it,” said Dr. Christina Ciaccio, an allergist at the University of Chicago. “Unfortunately, such a test doesn’t exist.”

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In addition, cutting out entire food groups carries risks such as malnutrition, particularly in children. (EverlyWell does not offer tests to anyone below the age of 18.)

And, though rare, symptoms such as bloating or headaches can be a sign of something more sinister, such as cancer. That’s why an elimination diet is best conducted under physician supervision.

When a person sees the doctor to learn about possible food intolerances, they’ll likely be irked to find that the cash they spent on food sensitivity testing ordered online or at an “alternative” practitioner’s office was money down the drain.

“Most patients in the end, when we have done our workup and come up with a plan,” Hartz said, “are actually quite frustrated that they spent all this money on a useless test.”

This story has been corrected to reflect the types of at-home blood tests offered by competitors. 

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  • Ummm… WHAT?! This test doesn’t even test for IgG. It doesn’t claim to! I agree with Eva below. I also have Hashimoto’s Thyroiditis and dropped my antibodies into the normal range. Gluten was my culprit! Conventional doctors need to catch up with the research and times or they will soon be obsolete! I am awaiting my sensitivity test from Everlywell to make further changes if necessary. It seems the fellow posters all see the light, too. We don’t fall for the “conventional” route of pushing meds and antiquated ideas (low fat) any longer!

    • From EverlyWells website…”The antibodies being testing are called IgG. As long as you have eaten a certain food within the past 4 weeks, the test should be able to detect those IgG levels. Conversely, if someone has removed a food from their diet for long periods of time, they may or may not still have IgG reactivity detected. It is possible for antibodies to change, however, it takes roughly 6 months for an IgG antibodies to leave your system completely. That means no eating any form or source of the food in question for at least 6 months. Our test looks at your current diet. If you are looking to add a potentially ‘problematic’ food back into your diet to see if you’re still sensitive to it on your test results, it’s recommended to consume that food for about 4 weeks prior to testing. Please be advised that if you experience symptoms while eating this food, you’ve already identified a sensitivity

  • If I had listened to conventional medicine doctors I would still be sick. I had to diagnose myself with an autoimmune disease and then get it confirmed through lab testing. It turned out I had Hashimoto’s. An autoimmune disease where your antibodies attack your thyroid. There is no treatment for autoimmune diseases in conventional medicine. Except drugs like chemo. These food sensitivity and vitamin deficiency tests help me get to the root cause of why I was so sick. My antibodies where in the 10,000’s and dropped to under 20.. I attribute these tests to helping me get my autoimmunity under control. It wasn’t something that happened over night. Food sensitivity testing is getting to the root cause not just treating symptoms.

  • Scare tactics in this one like ‘And, though rare, symptoms such as bloating or headaches can be a sign of something more sinister, such as cancer.’ Well if this is rare, then why did you mention it? You’re trying to scare people into the clinic with bloating and headaches …. nice.

  • looool. Listen, if we weren’t already at the ends of our wits with the medical system failing to help us, we wouldn’t be looking elsewhere. There is much to be learned by igg testing, and further, ongoing ingestion of igg trigger foods can cause much worse than a boring or difficult elimination diet- malabsorption and gut health decline play in to much more serious and insidious problems. Regrettably the western medical community’s knowledge in general is very limited and aggressively controlled. It also lacks the benefit of any wisdom.

  • Very poorly written article! Why not ask the Doctors who are using the test, what results are they getting? Of course these mainstream doctors are going to reject the test because they want to keep pumping you with medicines so that you stay sick! They don’t want you to eliminate the food and get better, that’s too easy!
    The ‘alternative’ practitioners ARE the ones to go to, they are healing you, the others are killing you!

    • Ha, so I still can’t speak to how well/if the EveryWell test works, but this article lost complete legitimacy as soon as it claimed that people were ‘irked’ about spending money on “alternative” practitioners…

      “When a person sees the doctor to learn about possible food intolerances, they’ll likely be irked to find that the cash they spent on food sensitivity testing ordered online or at an “alternative” practitioner’s office was money down the drain.”

  • the only thing that’s useless is this article, the same doctors who’s been telling people not to eat fat or reduce salt or to load up on “good carbs” are now against food testing? state news or more of the same old garbage…

    • Right?! Now of course we KNOW the whole low fat deal was to get people more addicted to sugar. Fat is where it’s at!

    • This article is annoying. I believe my chronic inflammation is due to food sensitivities cause by SIBO increased gut permeation. Now…. not to not eat garlic, eggs, and a whole host of food for 3 months.

  • This test helped my daughter. It told her to eliminate dairy and eggs and guess what, her symptoms disappeared. IgG indicates sensitivities. You need to balance this with good nutrition. It can work.

    • Food sensitivity testing helped my daughter eliminate problem foods. She has lost weight, eliminated daily tummy aches, and she has increased energy.

      When I had the testing done it told me to avoid some foods I had not had in over 40 years, therefore it was not reacting to foods recently eaten.

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