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It was a financial investment in a tobacco company that helped lead to the downfall of Brenda Fitzgerald, who until Wednesday was the director of the Centers for Disease Control and Prevention.

For many in the public health community, the notion that the head of the CDC held shares of a company in an industry that has been so anathema to the agency’s mission was shocking.

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But Fitzgerald also purchased shares in pharma giants Merck and Bayer after taking over the CDC — an apparent conflict of interest that also confounded government ethics experts.

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