I

t was supposed to be a $10 billion idea, one that would help wean the world off its opioid dependence and give the drug industry a bounty of lucrative new products.

But the bottom fell out for a new class of pain medicines, called NGF inhibitors, when patients in clinical trials starting inexplicably blowing out their joints. The Food and Drug Administration put a halt to further studies in 2010, and a bunch of once-transformational drugs suddenly looked like costly scientific mistakes.

Unlock this article by subscribing to STAT Plus. Try it FREE for 30 days!

SUBSCRIBE TODAY

What is it?

STAT Plus is a premium subscription that delivers daily market-moving biopharma coverage and in-depth science reporting from a team with decades of industry experience.

What's included?

  • Authoritative biopharma coverage and analysis, interviews with industry pioneers, policy analysis, and first looks at cutting edge laboratories and early stage research
  • Subscriber-only networking events and panel discussions across the country
  • Monthly subscriber-only live chats with our reporters and experts in the field
  • Discounted tickets to industry events and early-bird access to industry reports

Leave a Comment

Please enter your name.
Please enter a comment.

  • Those drugs are made in China and sold by the cartels. Your hurting people like me who is Chronic. Legalize Marijuana for everyone. No one ever got addicted from Marijuana. You’ll find that states that legal don’t have addiction problems

    • Opioid are a necessity for chronic pain equals 20 million people the other 80 million sell drugs opioids they are messing it up offer a reward and all is fixed

  • Thanks to all the over blown media sensationalism, I for one won’t have to worry much longer. Government has got what they wanted. I had my own flooring business for 44 yrs. until chronic pain took over my life. I’ve had more procedures than I can count, and opiates were the only things that allow me to live a normal life. Thanks to the actions of a few (May they rot in hell) I am now debating along with thousands if others, if living with the pain is worth it. Wish everyone could just walk a mile in my shoes. (But they could never stand it) Getting readt to lose everything I have ever worked for. Thanks for nothing

    • Don’t give up if you truly need opioids. Find a physiatrist (physical medicine/pain medicine) near you and make your case. If you can’t function and they restore function, you have a good case. That assumes you’ve tried half a dozen other things first and if you haven’t, that is on more reason to go see a physiatrist.

    • Also, if you haven’t tried hemp CBD, you should. Break the law if you have to, get it shipped to a friend in a legal state. It works as well as opioids.

    • Danny I am almost identical to you. I have had every procedure that is out there done. I then had 20 surgical procedures after the doctors finally listened to me and realized they were treating the wrong thing. Unfortunately they came within about 2 minutes of sending me to the morgue after a surgery and the nurse didn’t listen to me when I told her I couldn’t breath. I now have a nice scar from the emergency tracheotomy and a memory I relive every single day because what I went through was the most traumatic experience to date. My meds have been cut by more than half by my pain management doctor due to the new CDC guidelines and now I can barely get out of bed. Unbelievable!! There is a committee in Washington state that consists of 10 doctors and 10 nurses and would you believe that not a single one is in pain management. How is that even possible!? Good luck to all chronic pain people because it seems that is all we have.

  • Isn’t it true that as a peptide it would have to be given by the intravenous route? People aren’t going to want to stab themselves with needles, which will greatly limit its appeal. Maybe you could deliver it by the intranasal route, but that’s kind of chancy with regard to absorption.

  • If this drug causes joint deterioration, then it couldn’t be used in anyone with arthritis of any type. It might be good for post op use or maybe use in dental procedures.

    • It caused joint deterioration in individuals with osteoarthritis when used with NSAIDs because it worked too well. People resumed usage of their joints as though they weren’t arthritic and it caused them to deteriorate.

      That is danger, but it is danger I’ll take.

  • One significant finding for myself, as an individual who one day woke up, and was paralyzed. I could not feel anything, nor was I able to even get up to use the bathroom without the help of my husband. I was fifty-two years of age, and has never had any issues like this phenomenon before that fateful morning. I won’t go into the cause or a lot of other serious information about what we did to try to find help for the worst pain that I have ever experienced, when later during the morning, I once again could feel my body; but it was unbearable pain that came with my restored feeling like I never before had felt.

    Long long experiences short..I had a chronic extreme anxiety issue that I used Valium for many years of my adult life to help my anxiety.

    I decided that I wanted to stop taking all medications and explore other treatments for my anxiety. I found a great protocol that was established by a physician who had the protocol posted online. As a health care practitioner I had enough awareness about the brain and the ways that psychotropic drugs interacted with patients; so I followed the protocol and I have not been using Valium daily anymore.

    My observations were questionable as to the decision that I made about my new chronic pain situation. As an attempt to try to determine whether or not the Valium had been a significant way to not feel the horrible pain that caused me to spend years of my life with different treatments that were suggested by a number of physicians, one recommended that I try klonopin, in smaller doses to help with the remaining anxiety issues ( a family trait in numerous members of my paternal and maternal families ), and I have been using klonopin instead, each night for my help with sleep.

    I then tried using two mg of klonopin tid; the results of that were initially a non issue. I didn’t really find that this medication at the dosage was very helpful for my problem.

    I finally found a knowledgeable professional psychologist whose specialty is working with chronic pain issues. My life changed with his help.

    The treatment for chronic pain patients, must include the patient seek out treatment with a specialist who treats chronic pain in the therapeutic room of a qualified psychologist, in addition to other ways that a patient with chronic pain requires some safer medications, at lower doses, and the patient’s own perspective about the chronic pain issue, being explored in session with the psychologist, is the best treatment for chronic pain that took me years to find.

    I do think that the critical significant protocol of the anxiety as an apparent aspect of chronicity, regarding pain is of greater importance than most people ( including medical practitioners ) are aware.

    I would rather have a prescription for klonopin or even for Valium in certain circumstances, than Fentanyl; OxyContin; oxycodone; and the other opioids that are prescribed for the majority of chronic pain patients. There are some chronic pain patients who absolutely require opioids, in order to experience any quality of life; of this situation I have no doubt at all, and I am relieved for the patient who has some quality of life with the help of opioids.

    However, not all chronic pain patients are the same. I am still a proponent for anti-anxiety medications that are useful for the anxiety that I think all chronic pain patients suffer, and using klonopin or Valium is a significant relief for many individuals who have chronic pain issues.

    I would be very interested in knowing about this manner and it’s efficacy in helping individuals with chronic pain to ameliorate the pain, in order to have a quality life experience, without the opioids; they are not always indicated for a significant population of chronic pain patients and medications that are useful, instead of being a detriment for a significant amount of patients who want to have a quality of life, and continue to be able to have their professional lives with the treatment protocol that I have found that works well for me, and others who I know.

Sign up for our Morning Rounds newsletter

Your daily dose of what’s new in health and medicine.

Privacy Policy