On Wednesday, Biogen made an important announcement about its Alzheimer’s program, the one that puts billions of dollars and millions of hopes on the line. But it didn’t arrive via press release, and it wasn’t detailed in a filing with the Securities and Exchange Commission. Instead it was spoken softly by Dr. Al Sandrock, Biogen’s chief medical officer, before an audience of investors in New York.

“We did see more variability on the primary endpoint than assumed when we did the initial sample size estimations,” Sandrock said of two trials on aducanumab, the company’s all-important Alzheimer’s therapy. “So we decided to increase the sample size to maintain 90 percent power.”

Unlock this article by subscribing to STAT Plus and enjoy your first 30 days free!


What is it?

STAT Plus is a premium subscription that delivers daily market-moving biopharma coverage and in-depth science reporting from a team with decades of industry experience.

What's included?

  • Authoritative biopharma coverage and analysis, interviews with industry pioneers, policy analysis, and first looks at cutting edge laboratories and early stage research
  • Subscriber-only networking events and panel discussions across the country
  • Monthly subscriber-only live chats with our reporters and experts in the field
  • Discounted tickets to industry events and early-bird access to industry reports

Leave a Comment

Please enter your name.
Please enter a comment.

Sign up for our Daily Recap newsletter

A roundup of STAT’s top stories of the day in science and medicine

Privacy Policy