Frustrated by tepid sales and practical stumbling blocks, Regeneron and Sanofi are offering a huge discount on their treatment for bad cholesterol in exchange for a promise that health care’s biggest middleman will make it easier for patients to actually get the drug.

Starting in July, the two companies will sell their cholesterol-lowering drug Praluent, which carries a $14,600 list price, at roughly 60 percent off to clients of Express Scripts, the nation’s biggest pharmacy benefit manager. In exchange, Express Scripts will make their drug the only cholesterol-lowering injection available to the 25 million patients on its formulary, freezing out a rival therapy from Amgen. And, most important, Express Scripts will scrap the weeks of paperwork now required to approve a prescription, and implement a simple form that will allow doctors to get an immediate answer.

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