Biogen is declaring success with a once-failed treatment for Alzheimer’s disease, pointing to positive secondary results from a mid-stage study in hopes of saving a drug many in the field had written off entirely.

The treatment, BAN2401, failed its primary goal of beating out placebo over the course of 12 months. But looking at 18 months worth of data from the Phase 2 trial, Biogen (BIIB) and its partner, Japanese drug maker Eisai, said late Thursday that one dose of the treatment — the highest of five tested — had a significant effect on both cognition and the accumulation of toxic plaques in the brain.

Unlock this article by subscribing to STAT Plus and enjoy your first 30 days free!

GET STARTED

What is it?

STAT Plus is STAT's premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond.

What's included?

  • Daily reporting and analysis
  • The most comprehensive industry coverage from a powerhouse team of reporters
  • Subscriber-only newsletters
  • Daily newsletters to brief you on the most important industry news of the day
  • Online intelligence briefings
  • Frequent opportunities to engage with veteran beat reporters and industry experts
  • Exclusive industry events
  • Premium access to subscriber-only networking events around the country
  • The best reporters in the industry
  • The most trusted and well-connected newsroom in the health care industry
  • And much more
  • Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr.

Leave a Comment

Please enter your name.
Please enter a comment.

  • Hi,
    Please tell me how I could be part of the BAN 2401 Study or receive this medication. I have early Alzheimers & take care of my special needs daughter. I am an otherwise healthy 76 year old man who makes people laugh. Thank you very much, Anthony Robbins

  • Terrific work Biogen. Great news that this result showed slowing of decreased cognitive ability.
    The next step is to get the drug to correlate to increased cognitive ability. It will happen!

  • Anavex Life Science (AVXL) drug has a totally different mechanism than these other failed drugs and has shown very promising phase 2 data. Phase 2b/3 trial starting within the next month or two.

A roundup of STAT’s top stories of the day in science and medicine

Privacy Policy