During the recent Interim Meeting of the American Medical Association, the organization’s president, Dr. Barbara McAneny, told the story of a patient of hers whose pharmacist refused to fill his prescription for an opioid medication. She had prescribed the medication to ease her patient’s severe pain from prostate cancer, which had spread to his bones. Feeling ashamed after the pharmacist called him a “drug seeker,” he went home, hoping to endure his pain. Three days later, he tried to kill himself. Fortunately, McAneny’s patient was discovered by family members and survived.

This story has become all too familiar to patients who legitimately use opioid medication for pain.

Since the Centers for Disease Control and Prevention published its guideline for prescribing opioids for chronic pain in March 2016, pain patients have experienced increasing difficulty getting needed opioid medication due to denials by pharmacists and insurance providers.

advertisement

More troubling are recent press reports, blog posts, and journal articles that describe patients being refused necessary medication or those dismissed by their treating physicians, who practice in fear of regulatory reprisal. At the interim meeting, the AMA responded to these developments, passing several resolutions against the rash of laws and mandatory policies that limit or prevent patient access to opioid painkillers.

The CDC designed its guideline as non-mandatory guidance for primary care physicians. But legislators, pharmacy chains, insurers, and others have seized on certain parts of its dosage and supply recommendations and translated them into blanket limits in law and mandatory policy. Today, in more than half of U.S. states, patients in acute pain from surgery or an injury may not by law fill an opioid prescription for more than three to seven days, regardless of the severity of their surgery or injury.

Although many of these laws exempt patients with chronic or cancer pain, in practice they often affect those with long-term pain, like McAneny’s patient. Some insurance companies and major pharmacy chains, like Walmart, Express Scripts, and CVS, also have mandatory restrictions on the opioid prescriptions they will fill. In addition to imposing supply limits, insurers and pharmacies are increasingly using the CDC’s dosage guidance (the equivalent of 50 to 90 milligrams of morphine a day) as the basis for delaying or denying refills for long-term pain patients, even though the CDC guidance is intended to apply only to patients who have not taken opioids before.

The Drug Enforcement Administration and some state medical boards are also using this dosage guidance in ways that were never intended, such as a proxy or red flag to identify physician “over-prescribers” without considering the medical conditions or needs of these physicians’ patients. As a result, some physicians who specialize in pain management are leaving their practices, while others are tapering their patients off of opioids, solely out of fear of losing their licenses or criminal charges.

The laudable goal of these laws and policies is to stem the tide of unprecedented overdose deaths and addiction in the U.S. But here are three interesting facts: Opioid prescribing is currently at an 18-year low. The rate of prescribing opioids has dropped every year since 2011. Yet drug overdose deaths have skyrocketed since then.

Recent data from the CDC suggests that illegally manufactured fentanyl, its analogs, and heroin are responsible for well over half of all overdose deaths. Stimulants like cocaine and methamphetamines are responsible for another third. Deaths related to prescription opioids come next in line, although many of those who died were not the intended recipient of the prescribed medication. In addition, most deaths involve multiple substances that are used in combination, often including alcohol.

The vast majority of people who report misusing prescription opioids did not get them from a doctor under medical supervision, and as many as 70 percent reported prior use of substances like cocaine and methamphetamines.

Conflating the misuse of opioids with their legitimate medical use, and treating all opioids — illegal or prescription — alike is stigmatizing patients for whom opioid painkillers are necessary and medically appropriate.

There’s no question that taking opioid medications carries risks: The CDC places the risk of addiction with the long-term use of opioids at 0.07-6 percent. The risk of addiction justifies judicious prescribing, trying other forms of treatment before prescribing opioids, and carefully screening patients for a history of addiction and mental health issues when opioids are being considered.

But most patients who use opioid medication for pain do not become addicted, although they may develop physical dependence. Addiction is the compulsive use of a substance despite adverse consequences. Appropriate medical use is just the opposite, use on a set schedule as prescribed with benefits to health and function.

Nearly 18 million Americans currently take opioids long-term to manage pain; many of them have complex medical conditions. When appropriately prescribed opioids are denied, patients whose pain has been well-managed by them may experience medical decline, lose the ability to work and function, and resort to suicide. Denying opioids to patients who have relied on them — sometimes for years — may cause some to turn to street drugs, thereby increasing their risk of overdose.

Dr. Terri Lewis, a researcher and rehabilitation specialist, recently conducted a nationwide survey of 3,000 pain patients. More than half of those surveyed (56 percent) reported disruptions in care or outright abandonment by their physicians. Among those reporting disruption or abandonment, many experienced adverse health consequences (55 percent) as well as hopelessness or thinking about suicide (62 percent) as a result. In other surveys, physicians said that they were prescribing fewer opioids or ceasing treatment of pain patients altogether because of regulatory scrutiny, even in cases where they believed that doing so would harm their patients.

The CDC guideline and its progeny of laws and policies have created chaos and confusion in the medical community. Some physicians are telling their patients that changes in the law are the reason they are tapering them to a preset dosage of opioids or off of opioids altogether. Yet the specific dosage thresholds in the CDC guideline were never intended to apply to patients currently taking opioids. Indeed, nothing in the current legal or regulatory environment justifies forcibly tapering a patient off of opioids who is doing well, and there is no solid evidence to support such a practice.

Some physicians are also using the CDC’s dosage thresholds, or simply their patients’ use of opioids, as a reason for abandoning them. Abandoning pain patients out of fear of regulatory reprisal may violate a physician’s ethical duty to place a patient’s welfare above his or her own self-interest. If serious harm results from abandoning a patient’s care, it may also serve as a basis for discipline or malpractice claims. In addition, physicians and pharmacies have responsibilities under the Americans with Disabilities Act not to discriminate on the basis of a patient’s condition, including chronic pain, or a perceived condition, as when a person with pain is erroneously regarded as a person with opioid use disorder or addiction when there is no clinical basis for that perception.

The AMA’s recent resolutions formally push back against what the AMA calls the misapplication of the CDC’s guideline by regulatory bodies, legislators, pharmacists and pharmacy benefit managers, insurers, and others. The resolutions underscore that dosage guidance is just that — guidance — and that doses higher than those recommended by the CDC may be necessary and appropriate for some patients.

The AMA also took issue with the recent practices of regulatory bodies that subject physicians to oversight and potential sanction solely because of the opioid dosages they prescribe. Medicine involves treating patients individually, and weighing the specific risks and benefits of treatment in each case. Taking this capacity away from physicians hamstrings their ability to treat their patients — as does requiring them to practice in an environment of fear.

Epidemics instill fear, but physicians have a responsibility to rise above fear and advance the interests of their patients. The AMA’s action in advocating for patients and for the right of physicians to practice individualized care is an important effort in beginning to rebalance the scales in the joint goals of reducing pain and opioid addiction.

Kate M. Nicholson, J.D., is a civil rights and health policy attorney who served for 20 years in the Department of Justice’s Civil Rights Division, where she drafted the current regulations under the Americans with Disabilities Act and managed litigation nationwide. Diane E. Hoffmann, J.D., is a professor of health law at the University of Maryland School of Law, director of its Law & Health Care Program. Chad D. Kollas, M.D., chairs the American Medical Association’s Pain and Palliative Medicine Specialty Section Council and is the medical director in palliative and supportive care at the Orlando Health UF Health Cancer Center.

Leave a Comment

Please enter your name.
Please enter a comment.

  • I was on loratabs for 11 years , my pain clinic closed then reopened under therapix I had to change insurance , made a appt with a new I thought pain doc but to my surprise it wasn’t a pain doctorthen made another appt but was denied my medicine been wo since March tried kratom to hope it would help. Helped with some withdrawals I was having I honestly have lost so much muscle and in so much pain I can’t stop wanting to just lay down feel down enough I feel I’m giving up to a large degree I taught gymnastic for much of my life since being off I feel hopeless. But I’m being honest

  • I really hate to be the bearer of bad news, but this crisis is a money making machine for states. Even if the CDC released a statement today informing everyone today that it was all a bad April Fools Day joke it would take years to undo state legislation, Medicare guidance, pharmacy and legal insurance oversight. The State’s AG offices are going to ignore the message and target pharmaceutical companies with lawsuits anyways. I live in a community affected by a street drug crisis ( I don’t say “opioid” because the propaganda machine has applied the term to both legal and illegal street narcotics) and then I think of the Propaganda machine telling everyone that theses individuals started with a prescription drug. Wow, I mean I can’t hardly get around much less ride a bike, wear a backpack, haul property to pawn shops. The people I see are thin and young. If we apply this theory then why aren’t we seeing senior citizens who were receiving pain prescriptions for chronic arthritis on the streets looking for harder drugs to manage their addiction? Oklahoma just released 450 prisoners from their prison, a lot of them are meth abusers. I guess their stats were lowering and they needed more numbers to support more lawsuits.

    • Mr.Jeff u are correct,sadly..JMO,,What Andrea Kolodyn has done to pain management has destroyed it.I went to my forced 90 day appointment last week.Again we have to change my meds after being .O.K. for 10 years on the same dose,,no increase etc..For in Jan my insurance changes again to a different M.E. allowed,My Doc told me,,he use to treat 100 people,,,he is down to 10,,His own son,his 1 st born,went into the exact same field as his father,12 years of schooling,,He has chosen NOT to practice Pain management because of what Kolodny has done and the always threat of the DEA,, who does go after innocent Doctors.A friend of our use to work for the DOJ she quit,because she saw judges,dea agents setting up Doctors on TRUMP UP charges.
      What Kolodny has done is the same as the 1st person who called a women a ,”witch,”,,the 1st person who again wrongfully called the blacks race inferoir some how because of the color of their skin..its called A PREJUDICE,A IGNORANT FALSE JUDGEMENT WILFULLY DESIGNED TO DEGRADE A HUMAN BEING TO A ,”LESS THAN,” STATUS IN SOCIETY,,,By deeming a women a witch,it justified in ignorant minds to burn them at the stake for they were a less then a human species.Andrew kolodny has use thee age old archaic ,”group think,” prejudice,hatred,bias,discredit the victum approach to all medically ill in physical pain from their illness/condition..Ohh and lets not forget he is the chairmen of Physican mutual insurance company,,meaning,he insures Doctors,SOME who are more then willing to get their excuses so no patient can ever sue for pain and suffering again,,ie,,”Oh judge I was just following the cdc guidelines,and I was afraid said patient would become addicted,,that why no opiate medicine after my surgery,,”The truth however is far from his rationale,,he was a arrogant surgeoun,who f-up,,during surgery.Or the Doc who misdiagnoses a patient and refuses pain medicine,,claiming I didn’;t give the patient pain relief cause I though they mite become addicted..The point being he has given doctors their ,”out”,,,thus why many aren’t helping us!!!
      But the big one I see,,after 20 years dealing w/Doctors and 5 referrals to pain management,,is Psychiatrists were never welcome in Pain management..There’d be 1 office,,way down a long hallway,,always empty..As 1 shrink said on camera,,,there was no money in pain management at 1 time,,,now w/the shrinks like Kolodny cronies,,going to thee pseudo science side,ie,,ADDICTION,,,,AND I SAY FALSE FOR PLEASE SHOW ME ON A X-RAY WHERE ,”ADDICTION IS!!! not someone opinion where it is,,factually where is addiction.depression,suicide ideation,,where on the human body can this to be seen on a mri?Point being many educated minds have forgotten,,the field of psychology,psychiatry is that of opinion,,not physical fact,,and Andrea Kolodny has taken his licence to practice ”opinions” to abusive harmful ,deadly levels,by deeming the normal human behaviors of wanting physical pain caused by a factual physical illness/condition he has deem’d this normal behavior a ,”disorder,” a normal human behaviors’ of wanting physical pain lessen’d is now in insurance coding a ,”disorder,” labelled Andrea Kolody..and no-one that could stop him did?!!!
      Lets not forget all thos who have lost their jobs due to this ,”addiction madness,”Thee entire chain of Shopko stores closed down due to their pharmacy getting pulled into lawsuits.40,000 employees gone,,,Or the pain research departments at purdue,employed for 20 years,,”let go” their job position has been deleted.
      Point being,black folks are still looked upon w/a prejudice,,this is the same type of hatred Andrea Kolodny has set upon the medically ill in physical pain.The same type of hatred he placed upon our doctors,us and the medicine that allowed us to live life like ever dam person on earth is humanly legal to have.Soo people in physical pain from a illness Doctors screw up,deseases for every generation since Andrew Kolodny will be looked upon w/a hatred,a prejudice, for ever more,now..because those who had the legal knowledge and or authority did not stop him,,when they should of,,,Evil thrives when good men do nothing,,,OBVIOUSLY,,,maryw

  • Many years of years of opioid pain therapy brought me back to life. It gave me the ability to function, sleep and reacquire health. Until a few years ago when my doses were decreased to the CDC guidance levels, healing progress was evident. Physical activities and daily functions became part of my life again. Was able to walk and ride a bike. Taking care of daily chores was once again something I could manage for myself. Not having to depend on others to live was beneficial to health and well being. The past two years have been lacking
    all those achievements. Now in decline, I feel abandoned and left to wither.
    Is there someone who can help ? Is there someone who really cares to advocate for those in pain ? Thank you for this article.

  • I have also been cut unfairly I have been diagnosed with many autoimmune diseases and bone diseases, and have busted every bone in my body with no chance of healing or surgery due to too many broken bone especially in my back I even have lost over 5in in heighth, I finally had a decent quality of life for many years until pain specialist steps in under new guidelines and say I have to be brought to guidelines as well and cut astonishing amounts at a time landing me in the hospital many times then I see him and he just says we’ll still have to cut it anyway even when I busted my hip cut again.

  • We need to remove all restrictions on opoid prescribing. Years ago, when I was refused such a Rx., I went out and scored heroin just to prevent withdrawals and function normally. I can see why this is happening alot.

  • Currently my quality of life is threatened due to the cdc’s suggestions to limit my pain medications. I have both RA and osteo. I live in Alaska, weather affects me. I have been on the same level.of pain meds for 15 years. I never break any rules or laws yet my pain specialist tells me I am being tapered down to the cdc’s idea to the 90 mil limit and he is not losing his license for anyone.

  • My name is Clark zaccardi and my girlfriends name is Amy sandal and we are both dealing with the ongoing effects of the after birth of opiate addiction from extreme over prescribing for long term use and then one day out of the blue both of us being cold turkey off the opiates to a cold turkey status and both of us resulting in searching out illicit street drugs Meth which has caused us both trouble with the law and becoming homeless and loosing everything we own because of the domino effects from the with drawing off the opiates in this fashion I my self was on over a hundred milligrams of opiate S for many years everydayand has caused us such devastation I’m our lives for more information from both of us you can reach us back in person at 16123578795

    • Mr.Clark,,,can I ask,,are u over 21 years of age??Did u lie to your Doctors and Tell him/her u had physical pain,,or do u have physical pain from a medical condition?If your complaining about a doctor giving u pain relief,,why?If u are over 21,,at ANY TIME,,U COULD OF SAID NO,,I DO NOT NEED/WANT PAIN RELIEF MEDICINE,,,,WHY DID U NOT USE YOUR ,”INFORMED CONSENT,” AS AN ADULT??ALSO,, do u believe its right that all medically ill in physical pain are now FORCED TO ENDURE THEIR PHYSICAL PAIN BECAUSE OF THIS ,”ADDICTION,” U CLAIM?Can u show me on a x-ray where is this ,”addiction,”,,where is it???Point being addiction is a opinion,,like all of psychology/psychiatry and if their gonna make money claiming ,”addiction epedimic”,,,verses pain medicine works,,,which do u think their gonna choose??THE $$$$$$,,,AND LIE BY LIARS ALL OVER INNOCENT,MEDICALLY ILL HUMANBEING,,CLAIMING THE ADDICTION CARD NOW A DAYS NOT TO GIVE US PROPER MEDICINE FOR PHYSICAL PAIN,,DO U REALIZE HOW THIS ,”ADDICTION ,” LIE HAS BEEN WEAPONIZED AGAINST TRUE MEDICALLY ILL PEOPLE IN PHYSICAL PAIN??LITERALLY TORTUREING THEM,,SOME TO DEATH VIA FORCED ENDUREMENT OF PHYSICAL PAIN FROM MEDICAL CONDITIONSmaryw

  • I’m going to be very careful with my words here (much like President Donald Trump does lol)…I was prescribed copious amounts of opioids for decades following countless surgeries, particularly oxycodone, simply because every alternative narcotic analgesic produces numerous extremely unpleasant side-effects and/or, I was proven to be allergic to them. My EX doctor (name withheld to protect the guilty…cough Wendy..Cough Graham… of 15 years of spotless record with her, cut me off opioids cold turkey and hands me a marijuana prescription in lieu of opioids while saying in front of at least 15 strangers, “We’re going to stop making you a druggie and give you this…” Marijuana certainly helps, but it doesn’t replace the effectiveness of the oxycodone. Now my “pain doctor” who really doesn’t seem to want to know about my pain at all, made me pee in cups thrice a week, see him once a week, after telling me personally that he thinks methadone is “shit” …”garbage” “…we only give it out because it’s the easiest thing to do (his words basically). OK, if you’re concerned somebody is going to die from my recklessness, then don’t give me a bottle of them at once…if I have to physically go uptown everyday to get my pain meds, then let me choose the medication (fair), and don’t treat me like a drug addict plain & simple. I KNOW THAT…YOU MADE SURE I KNEW THAT. Now, I finally begged him to give me Oxycodone in some form…for my pain period. I don’t understand that if i am on methadone for addiction or pain or both, you can get it increased at YOUR discretion. Today, I’m going to ask the doctor if he could prescribe me two 40’s per day, one in the morning, one at night, perfect…and I’ll never ask him for another increase for the rest of the rest of my lives. He’s the doctor, they don’t enjoy being advised by patients…deemed as being told what to do perhaps…I only want pain relief Bones, pain relief for the entire 24 hours of the day, not just 12 to 18 hours…look, I was once on 300mg of OxyContin per day…three 80mg plus three 20mg per day…WAY WAY too much for a terminal cancer patient in my opinion. Nobody protected me from this EX doctor, and nobody cared what she did, it’s like she cannot be punished…because it’s true. If i hurt her as much as she has me, I’d be in prison. Fact. I now have to carry a grey plastic box with a tiny lock & key to carry around my 5 or 6 or 10 day carry allowance…IF I earn that. You must earn your take home pain killers!!!. I’m 60 years old soon, had both knees replaced after they did every surgery possible in between that, I may require a hip replacement, I had a foot long titanium rod inside my busted in half femur bone then the fracture radiated through my pelvis and into my bottom vertebra…I need to be able to function, and oxycodone helped me do just that, and happily. What the fuck part of these things we tell you don’t you understand? The folks that Overdosed and/or died from some opioid, I know NONE of them….why are you punishing me for someone else’s faux pas? YOUR FAUX PAS? I’m pissed…and getting pissier…

  • Great article! Thank you so much. I wish I could find a group that advocates for people like me who had Scheurermann’s Disease as a child and Spondylolysis and spondylolisthesis

A roundup of STAT’s top stories of the day in science and medicine

Privacy Policy