Curing diabetes with stem cells? Everyone knew that would be hard. Parkinson’s disease? Harder. Alzheimer’s? Probably impossible. But age-related macular degeneration, a major cause of blindness? That was supposed to be low-hanging fruit.

The cause of AMD is well-known, the recipe for turning stem cells into retinal cells works like a charm, and the eye is “immunoprivileged,” meaning immune cells don’t attack foreigners such as, say, lab-made retinal cells. Yet more than a decade after animal studies showed promise, and nearly eight years since retinal cells created from embryonic stem cells were safely transplanted into nine patients in a clinical trial, no one outside of a research setting (or a rogue clinic) is getting stem cell therapy for macular degeneration.

That may change soon. Researchers in California expect to launch a Phase 2 clinical trial of stem cell therapy for age-related macular degeneration this year, while a team from the National Institutes of Health is not far behind: It is planning the first U.S. clinical trial using what are called induced pluripotent stem cells, which were discovered 12 years ago and won a 2012 Nobel Prize. These cells (iPSCs, for short) are made by sending plain old adult cells back in time, biologically, until they’re like embryonic stem cells — but without the ethical baggage those cells carry.

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“When iPSCs were discovered in 2007, there was a lot of hype that we could easily turn them into therapies,” said Kapil Bharti of the NIH’s National Eye Institute. “But there were many unanswered questions” about how to safely make transplantable cells, questions that are only now being answered. “I hope this reignites the field,” Bharti said.

A handful of other iPSC-based clinical studies of various kinds are ongoing in Japan and China, while San Diego-based Fate Therapeutics recently received clearance from the Food and Drug Administration for an iPSC trial in the U.S. to treat solid tumors.

Bharti and NEI colleagues reported in Science Translational Medicine on Wednesday that they had used retinal cells created from human iPSCs to treat a form of macular degeneration in rats and pigs, with results promising enough that they hope to start recruiting macular degeneration patients for a clinical trial in the next few weeks.

That sets up a face-off between two forms of stem cells. In their trial, scientists at the University of Southern California are starting with stem cells derived from human embryos.

“You know where we are putting our bets,” said Dr. Mark Humayun of USC’s Keck School of Medicine. But “in general, cell replacement therapies are a promising approach in the treatment of AMD. So both [kinds of stem cells] should be explored.”

Advanced “dry” age-related macular degeneration is a leading cause of blindness among people older than 50, affecting about 11 million people in the U.S. There’s no effective treatment. It’s caused by the death of retinal pigment epithelial cells, which form a nutrient- and oxygen-rich layer in the eye that keeps the rods and cones alive. When RPE cells die, due to age or high blood pressure or smoking or other causes, so do those photoreceptors, resulting in blindness.

In the NEI study, scientists led by Bharti started with blood-making cells, called CD34+ cells, isolated from the blood of three AMD patients, and then turned them into iPSCs. They added growth factors and other biochemicals that shape the cells’ destiny: Although pluripotent cells can become any type of cell in the body, the specific combination of biochemicals produces one and only one. Bharti and his team created retinal pigment epithelial cells, the kind that die early in macular degeneration. Each batch took about 11 weeks.

The idea is that replacing the dead and dying RPE cells “will stop these photoreceptors from dying and stop the disease from getting worse,” said Bharti, who with two co-authors are inventors on a patent application for generating retinal cells from iPSCs. Saving RPE cells wouldn’t bring photoreceptors back from the dead, and restore lost vision. But he and his team are already developing an AMD therapy combining photoreceptors with an RPE patch. That could actually cure AMD blindness.

Although a prominent 2011 study injected droplets of retinal cells created from embryonic stem cells into nine AMD patients, Bharti did it differently, growing the cells in monolayers on a biodegradable scaffold. Carefully slipped between the retinal pigment epithelial cells and the photoreceptors of rats and pigs with a version of macular degeneration, the scaffolds melted away and the cells (about 2,500 for the rats, 100,000 for the pigs) integrated within the retina better than cells in injected droplets did. They did not, however, test the animals’ vision.

“I think this paper provides extremely valuable insights,” said Dr. Robert Lanza, head of regenerative medicine at Astellas Pharma US, a division of the Tokyo-based drug maker, and co-leader of the 2011 AMD study using embryonic stem cells. “I completely agree there is need for robust manufacturing and functional evaluation of RPE cells [as the NEI team did] before clinical use.”

Lanza isn’t sold on the patch approach, however. “I don’t buy their argument that using a scaffold is superior to using a cell suspension,” he said. “Transplanting a scaffold is clinically very challenging and is associated with a host of potential problems, which is why some groups have abandoned that approach.” The NEI team got results comparable to those from the patch when they injected more RPE cells, Lanza noted, which “suggests it may be the more minimally invasive way to proceed.”

Nevertheless, other researchers are also going the patch route. A London-California team reported last year that two AMD patients who received a patch with a monolayer of retinal pigment epithelial cells (produced from cells taken from human embryos, not adult cells) experienced no serious side effects. After a few weeks, one patient could see an additional 21 letters on a standard eye chart and the other could see 29 more.

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At USC, Humayun and his colleagues transplanted RPE-covered scaffolds into four AMD patients, with no red flags over safety and with hints that it might improve vision, they reported last year: With one eye, one of the patients could see 17 more letters on the standard eye chart than before. The USC team plans to launch a Phase 2 clinical trial this year, Humayun said.

One worry about cells produced from induced pluripotent stem cells is that some of the iPSCs might not become specialized cells in the biochemical bath. Pluripotent stem cells can grow into tumor-like teratomas. But the NEI team got up to 96 percent of the stem cells to differentiate into RPE cells, and detected no such problem.

Nor did they find cancer-causing mutations in the induced pluripotent stem cells, something scientists warned about in 2017.

One remaining concern is that the same underlying cause of a patient’s original macular degeneration might also doom the transplanted cells. But since it took decades for disease to appear the first time, Bharti said, a cell therapy at age 60 or 70 has a good chance of lasting the rest of a lifetime. If the clinical trial gets promising results, he said, NEI will look for a commercial partner to move the therapy forward.

Correction: An earlier version of this story and its headline wrongly characterized the planned National Eye Institute trial. It will be the first in the U.S. to test a therapy in humans derived from induced pluripotent stem cells.

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  • Looking for more info about the clinical study for the stem cell for advanced dry macular degeneration.

    Thank you

    Jayne kramer

  • AMD affects my family for generations. My great grandmother, grandmother, now my Mother. She is age 76 and has loss vision in one and now the other is 20/70. She would be an excellent study. Any information or updates will be deeply appreciated.

  • I am more than interested in this study. I am 77 years old and have wet AMD in one eye (had Avastin 3 times but no longer) and dry AMD in right eye which is progressing rapidly. Would like to know how to sign up for study or related inoculation.  Thank you

    • I am 58 and have wet AMD in my right eye and dry in my left left. The therapy I’m getting now is working fairly well, but the doctor did not mention to me that I should be taking fish oil and centrum silver. I found that out on my own and just want to share wherever possible!

  • As a RN, in practice for 45 years, to me this is the next “sliced bread “, or big breakthrough since penicillin. So many people can be helped with stem cell therapy, cord cells (MSC’s) are awesome. My mother has AMD and sister has early stages. I haven’t yet but want something there to help if I do. Would love for my 89yo Mom to be able to see her grandkids and read like she always did, or watch the Spurs on TV as she loves them and loves to garden. But not seeing anything sure cuts her quality of life.

  • I duffer AMD and my right eye is no use at all. I can just see my way. It has been so since 1999 when I was 62 years old. My right eye strted deteriorating two years ago and I take eyelia shots. I can read enlarged script on I pads but not a newspaper or ordinary books.
    Hoping to hear the good news about new therapies soon.
    SABAH

  • My mom has AMD (Dry) and I was wondering how she could be evaluated to be in the trials? She still has some peripheral vision, uses a “White Page” Kindle with largest font to read, but is getting worse. She is 89, no dementia, has some physical aches and pains, but if could see better,would be out working on patio plants and being more active. Dreads the time she won’t be able to use the kindle. LOVES the San Antonio Spurs and tries to watch them on TV (lives in San Antonio area) every time they are on. Cannot see enough peripherally to keep up with the action. Any ideas would be appreciated.

  • What is your opinion about Coconut Oil being recommended as well as Spinach for Improvement on ones vision and in some instances very helpful for the Macula Degeneration. I cup of spinach daily and 2 Tblspn. of coconut oil and Fish at least 3 times a wk such as Salmon, Tuna Fish or Sardines. Thank you

  • Need to know if there are Specialist Doctors for low vision here in St Goerge, Ut or do I need to go to Ca. If yes could you recommend one.
    I have Macula Degeneration need a doctor for help in prescribing reading glasses. The ones I have are not strong enough.Thank you

    • I am very interested in this study. I have lost the central vision in my left eye due to wet AMD and am told the right eye is rapidly loosing sight from AMD that is dry. Is there anything to be done and is it wise to try now before it gets worse, or does that matter? Thank you so much for answering my questions. I don’t know where to turn?

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