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Traditional clinical trials are the gold standard for determining whether a new medicine is safe and effective for its intended use. But some companies, as well as the Food and Drug Administration, are increasingly focused on the question of whether “real-world evidence” can change the way medical researchers study patients — and perhaps even replace control groups in some cases. Join STAT’s senior medicine writer, Matthew Herper, for a subscriber-only live chat on how some experts hope to use real-world evidence and why others are deeply skeptical.

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