Alzheimer’s disease has beaten back another effort to tame it.

Biogen and its Japanese pharma partner Eisai said Thursday that they were halting two Phase 3 clinical trials of aducanumab, a drug that was designed to slow the worsening of Alzheimer’s by targeting brain-destroying protein fragments known as beta-amyloid.

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  • I have lost 3 sisters to Alzheimers, a 4th has symptoms/signs of significant memory loss and I can tell that I am beginning to. Our family and many others had hopes that this drug would prove viable. Please, don’t give up or at least share your research with other neuro groups so progression on the development of a drug to at least slow down brain damage can continue. Thank you.

    • Don’t lose hope, Roche will make announcements about its medication to cure alzahimer called gantenerumab most probably end of this year

  • Given that this is so hard, in the meantime, can we please stop putting mercury in human teeth, eat healthy, exercise, and cover heavy metals and chemical toxins screens every five years or so, with appropriate treatment to give our body, brain, cells, gut, organs, nerves and systems a fighting chance?

  • Perhaps some day, the pharmaceutical industry will learn that in Alzheimer’s prevention is the key. Treatment of a disease where neural damage is irre versible is wishful thinking. Aducanumab was isolated from health cognitively normal older people, not from early late Alzheimers. I guess that short of a brain transplant, at the state of the art treament is an empty word. Focus on prevention, but design the studies in an intelligent manner and not like the past circus of Alzheimer’s drug development.

  • All these studies when Acupuncture has the best outcomes. If Acupuncture placebo works marvelously than other drugs, please give us acupuncture.
    Acupuncture dominates the nervous system.

    • T. Trust — This is possibly the most ridiculous and unsupportable suggestion I’ve ever seen for treating Alzheimer disease. Acupuncture is a fraud for treating neurological diseases. If you can find even one tiny shred of evidence, please post it.

    • Go read? This is right from the loonies’ playbook. Make an outrageous and totally unsupported claim, then tell the sane one to go look it up. It ain’t there, and you know it.

  • Unfortunately I predicted this years ago when the phase 1 trials came out and Biogen jumped to a phase 3 trial. I warned all who would listen that the meager results of the initial trial did not justify further investment but was roundly ignored.

  • What happens to the trial participants now? Is there any followup? Do they still get the scheduled followup?

  • This is heartbreaking news for all the current and future Alzheimer’s patients and their families, as well as the employees and contractors of Biogen who gave their all to make it work. A sad day indeed.

    • Probably plaque is a secondary result of the problem. It was known that some people got plaques without the disease symtoms and others got the disease symptoms without the plaques.

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