When superstar cardiologist Dr. Sekar Kathiresan cataloged genes associated with coronary artery disease, he found nearly 60: some that decimate blood levels of LDL (“bad cholesterol”) and therefore protect against heart attacks, some that cause inflammation of arteries and so raise the risk of heart attacks, and scores more with effects on triglycerides, blood vessels, and other risk factors.

While existing drugs mostly operate far downstream of the genes, Kathiresan thought therapies operating at the level of DNA would let cardiologists “reimagine how we treat coronary artery disease, permanently protecting against it,” he said.

Unlock this article by subscribing to STAT Plus and enjoy your first 30 days free!

GET STARTED

What is it?

STAT Plus is STAT's premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond.

What's included?

  • Daily reporting and analysis
  • The most comprehensive industry coverage from a powerhouse team of reporters
  • Subscriber-only newsletters
  • Daily newsletters to brief you on the most important industry news of the day
  • Online intelligence briefings
  • Frequent opportunities to engage with veteran beat reporters and industry experts
  • Exclusive industry events
  • Premium access to subscriber-only networking events around the country
  • The best reporters in the industry
  • The most trusted and well-connected newsroom in the health care industry
  • And much more
  • Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr.

Leave a Comment

Please enter your name.
Please enter a comment.

  • Congratulations to Sek K…for having tremendous vision and taking a bold steps to make it happen. Targeting elimination of atherosclerotic cardiovascular disease (heart and vascular) disease, the leading cause of death in the US, is a wonderful goal. Skeptics beware, Dr. Kathiresan is brilliant, strategic, and a force of nature. If anyone can drive this to successful outcome, it will be Sek. Best of luck and we are all rooting for you!

A roundup of STAT’s top stories of the day in science and medicine

Privacy Policy