Biocryst Pharmaceuticals (BCRX) said Tuesday that a first-of-its-kind oral therapy for a rare, genetic disease called hereditary angioedema successfully reduced the rate of swelling “attacks” experienced by patients compared to placebo, achieving the main goal of a Phase 3 clinical trial.

But the magnitude of the benefit demonstrated by the Biocryst once-daily pill, called BCX7353, was relatively small, raising investor concerns that the new therapy, while convenient for patients, will find it difficult to compete against more effective injectable medicines already on the market.

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