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Sanofi (SNY) and Regeneron Pharmaceuticals (REGN) said Friday that a monoclonal antibody drug targeting a protein called IL-33 provided no additional benefit to asthma patients when added to the already approved drug Dupixent.

The disappointing clinical trial results raise questions about the future role that anti-IL-33 drugs might have in treating asthma and other inflammatory related diseases. Shares of AnaptysBio (ANAB), a biotech with a similar drug in mid-stage development, fell 16% in reaction to the negative news from Sanofi and Regeneron, whose share prices were unchanged.

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