Seizing on the surging popularity of at-home DNA testing kits, top academic medical institutions are opening clinics that promise to probe much deeper into your DNA — if you’re willing to pay hundreds or even thousands of dollars out of pocket to learn about disease risks that may be lurking in your genes.
Genomic sequencing programs that cater to apparently healthy adults have been started in the past few years at the Mayo Clinic; the University of California, San Francisco; and the HudsonAlpha Institute for Biotechnology, a nonprofit research institution in Alabama. Now, two top Boston hospitals are getting into the potentially lucrative business.
Brigham and Women’s Hospital on Friday unveiled a new Preventive Genomics Clinic that will offer a menu of options for a genetic workup, with price tags ranging from $250 to $2,950, depending on how many genes are analyzed; it’s the first program of its kind that will offer the sequencing to children in addition to adults. And next month, Massachusetts General Hospital plans to launch its own clinic for adults that will offer elective sequencing at a similar price range as the Brigham.
By scouring hundreds or thousands of genes — far more than most consumer genetics companies — representatives for these clinics told STAT that, in a small fraction of patients, they’re helping diagnose mild genetic diseases as well as turning up markers of elevated risks for conditions both common and rare. The test results allow clinicians to offer further guidance to patients, whether that means encouraging them to take proactive steps such as getting a preventive mastectomy or counseling them to just be more diligent about a screening that was recommended anyway.
“I think there’s just more and more interest from patients and families not only because of 23andMe and the like, but because there’s just this understanding that if you can find out information about your health before you become sick, then really our opportunity as physicians to do something to help you is much greater,” said Dr. David Bick, the clinical geneticist who directs the elective genomics program at HudsonAlpha. Close to 50 adults have each paid $7,000 for whole genome sequencing and interpretation since HudsonAlpha launched the offering in 2016, Bick said.
Dr. Robert Green, a medical geneticist leading the new clinic at the Brigham, is candid about the limitations of advanced sequencing programs. “It’s clearly not been demonstrated to be cost-effective to promote this on a societal basis,” he said. It’s evident too, he said, that such sequencing leads to pricey follow-up testing.
“The question that’s hard to answer is whether there are long-term benefits that justify those health-care costs — whether the sequencing itself, the physician visit, and any downstream testing that’s stimulated will be justified by the situations where you can find and prevent disease,” Green said.
Insurers sometimes cover deep genomic sequencing when there’s a clear medical reason for it, such as for people with a long family history of cancer. (The soon-to-launch clinic at Mass. General will offer such medically indicated testing, too.) By contrast, insurers generally refuse to cover the elective sequencing offered at the clinics sprouting up at top academic medical centers. There’s not yet strong evidence to indicate that apparently healthy people derive widespread benefits.
The result is that the new clinics generally serve only those who can afford to pay cash. That worries some in the medical community.
“The idea that genomic sequencing is only going to be accessible by wealthy, well-educated patrons who can pay out of pocket is anathema to the goals of the publicly funded Human Genome Project, and creates new disparities in our health care system,” said Dr. Jonathan Berg, a genetics professor at the University of North Carolina.
As more preventive genomics clinics open their doors, some report that demand is surging.
The Mayo Clinic offers elective sequencing at its flagship sites in Minnesota, Arizona, and Florida, as part of a program that is aimed at business executives. The genomics offering soft-launched in 2014, and has gradually attracted more interest each year. But demand “really started to take off” last year, after sequencing was added to a menu of options for executives interested in a medical workup, said Teresa Kruisselbrink, a genetic counselor who manages the team at Mayo that helps patients interpret these results. More than 1,300 adults signed up to get sequenced last year.
Other clinics, though, have seen less interest.
Since UCSF opened its preventive genomics clinic in 2017, a few hundred people have paid to get genomics panels ranging from about $300 to $800, or for more thorough exome sequencing ranging from about $2,000 to $2,500. Dr. Aleksandar Rajkovic, UCSF’s chief genomics officer who leads the clinic there, said he was a bit surprised that demand hasn’t been higher.
One reason for the modest demand, he mused, is that UCSF hasn’t heavily advertised the service. Another? “Most regular physicians are not really recommending it because at this point in time there really haven’t been studies that show significant clinical utility of doing these testing in healthy populations,” Rajkovic said.
One of the priciest high-end sequencing offerings is a commercial one, from Human Longevity Inc., the San Diego company founded by genomics pioneer Craig Venter. In 2015, HLI launched an extraordinarily in-depth medical workup, including genetic analysis, for $25,000. Seeking to bring in more customers, the company started offering discounts, dropping the price to $4,950 as of last summer. (HLI didn’t return STAT’s requests for comment on current pricing.) But that business hasn’t grown as quickly as executives and investors hoped, the Wall Street Journal reported last December.
At the new clinic at the Brigham, which is expected to primarily draw people from the Boston area, Green said he’s not worried about demand.
“We’re not trying to make a profit — we’re trying to offer a service in a medically responsible way. And so if a very modest number of people want to use it, that’s fine,” Green said. “What we’re trying to say is that people are using this, whether it’s HLI or consumer-facing laboratories over the internet, and we’d like to provide them with an alternative.”
Green’s new clinic at the Brigham grew out of his work on several of the most ambitious research studies aiming to assess whether thorough genomic sequencing is worth it. One was BabySeq, a study of 360 newborns that randomly assigned half of the group to get genomic sequencing and the other half to get standard screening. Another was MedSeq, a study of 200 adults that randomly assigned participants to either get their genome sequenced or their family medical history analyzed.
The Brigham’s new clinic has quietly seen a couple dozen patients since a soft-launch last winter.
One of them is Nicole, a Boston-area entrepreneur in her 40s who requested her surname not be disclosed because she does not want insurers to know that her genome has been sequenced.
Nicole, who was connected to STAT by representatives from the Brigham, said she learned about the new offering at a fundraiser in New York supporting Green’s research.
To decide what to order, Nicole read through a menu offering genomic sequencing and gene panel tests, including several offered by genomics companies. After weighing her options, she decided to move forward with a $2,950 offering, to be run by a laboratory operated by the Boston area Partners HealthCare system, that would scour more than 3,700 of her genes for disease risk. She also added on a $349 test from the company OneOme that promised to analyze her DNA to see how it influences the effectiveness of certain medications. (Green is a paid adviser for several genomics companies, including Veritas Genetics, one of the companies on the Brigham clinic’s menu of offerings.)
It was a bit expensive, Nicole said. But she already invests heavily in diet and exercise, and saw sequencing as one more thing she could do for her health. And she didn’t want to wait for the price to go down, she said, because of the risk that disease could strike in the interim. “If there’s preventative actions that I can take now as compared to later, then I’d rather know,” Nicole said.
At the Brigham clinic last week, Nicole got her blood drawn and her cheek swabbed. It was part of an extensive visit that each patient goes through before the sequencing is performed, involving taking a medical history and undergoing a full physical examination meant to help guide decisions about follow-up testing and other care. She’s expecting to return to the clinic in a few months to get her results — and to talk through what they mean and how to proceed.
So far, insurers have generally paid for the initial and follow-up visits to the Brigham’s clinic. Without insurance, the initial visit tends to cost around $1,000, and the follow-up visit may go for a few hundred dollars.
While the Brigham’s new clinic is offering people a purely clinical service, it involves an optional research component, too. Most of the Brigham clinic’s first patients have agreed to participate in PeopleSeq, a study funded by the National Institutes of Health that aims to track the long-term outcomes of people who’ve gotten thorough genomic sequencing. (The cost of the sequencing is not waived if they agree to sign up.)
The study’s goal is to follow thousands of patients across the country for as many years as they’re willing to complete an annual online survey that will ask basic questions, like whether the person has developed cancer or a thickened heart wall, or faced insurance discrimination. “We have no data on so much of this,” Green said. “It’s all been in the realm of speculation.”
KATE – Thanks for your post. While, as I posted earlier, I would never get this testing just to be preventive, I appreciate your post that when someone is ill and can’t get a good diagnosis, genetic testing may in fact be the right thing to do.
So glad it worked out for you and your husband.
After 9 specialists were unable to diagnose and was found to have rare neurological symptoms, my spouse took a series of SNP panel tests for around $600 and had Livewello interpret the raw data for an additional $50, and then let two separate persons help us look at the results privately. One was a molecular biologist, the other a licensed integrative neurologist. What we gleaned from those tests saved my spouse’s life. Without them we would never have realized he has a rare combination of key methylation and transsulfurstion SNP mutations, which could be manipulated through targeted nutritional therapies. We later had him tested for chromosomal abnormalities at Emory, and found his only health issues stemmed from the SNP mutations. Today he is on a great road to living a normal life. Testing is not necessarily a scam. You must be smart about where you test and what tests you chose
One good thing about insurance not paying for these tests, they don’t have the right to know the results, and you don’t need to give them access. In fact you don’t need to tell them you have had the tests. So, if you are prone to something, they can’t exclude you.
A good point!
While insurance doesn’t pay for these tests they have access to your medical records (because they are paying for other services). You may incur or need other services based on your test results (preventative screening or surgeries). Yes, health insurance cannot discriminate against you based on your results.
Protections do not cover NEW life or long-term care insurance policies. If taking out a policy they will ask to access your medical records. Also, they may ask you if you’ve had genetic testing. Lying about that can forfeit your coverage. Just food for thought! 🙂 I’m a nurse not an insurance expert by any means. Look up GINA for more information if interested. Best!
I would not lie, but tell them that it is private information, and they have no need to know. If they don’t give me the life insurance, they lose my money. As to follow up medical, there are other tests that my Doctor could give me as a part of my annual physical that can explain any other follow ups. (Based upon what I say when he asks about how I am.
Some of the mutations in these tests are awful! They could drastically increase your risk for diseases. It would be hard to explain to your insurance company and you would need medical justification for a radical prostatectomy, stomach removal, bilateral mastectomy, etc. Yes, those are more extreme but definitely not covered in your annual exam.
These people are crooks. New techniques enable sequencing for very low cost $2500 is ridiculous.
The machines are very expensive that do these tests and a lot of manpower. Ancestry DNA and 23 and Me only price theirs low in hopes you will buy some of their add on services. $2,500 if affordable for some people (not me) but yes, expensive to others. Lots of cost involved and the price has decreased dramatically in the last few years.
The overhead is very high for these tests. The machines alone are thousands of dollars. They have to pay for personell, sample storage (refridgerators), etc. 23 and Me and Ancestry DNA only charge so little in hopes you will buy some of their add-on services. $2,500 is reasonable for some, I cannot afford it but there are many lower cost tests ($250) that are just as good. 🙂
Epigenetics … just because you have a gene that is “bad,” doesn’t mean it will be turned “on” or remain “off” … thus agree with all commentors below. The stress of knowing you COULD come down with a disease isn’t worth it, nor are the privacy implications
I think that this type of testing is counter-productive, and I have no interest in it.
I think that finding out you have a risky gene would cause horrible stress, and then endless testing forever, which would continue the horrible stress. And, lots of that testing wouldn’t be insured, and so there could be true financial harm.
If someone is so concerned about future health, then I advise that they eat properly, get some exercise, wear seatbelts, stay off their phones while driving, take some good vitamin/mineral supplements, wear helmets while biking, etc — i.e. — simply take good care of yourself.
Genetic testing could also increase risk of problems in all other areas of your life — insurers denying coverage; potential employers denying jobs; potential romantic partners not wanting to get involved.
There is such a thing as too much information.
I have no interest in this, even though I have intractable chronic pain and a host of other problems.
I’m on Medicare and so some general concerns dont’ affect me personally, like the obvious privacy concerns — insurers finding out any “bad” genetic info will certainly deny insurance; prospective employers could also deny jobs to people with risky genes; and more.
But simply, I think that there’s a limit as to what’s good to know.
Think of the incredible stress that could result when someone finds out they have a risky gene. And the endless testing etc that could result. More stress. People could drive themselves crazy worrying about something that might never happen, and also bankrupt themselves on tests and procedures that aren’t insured.
If someone is that concerned about their future health, then they should eat properly and get some exercise, take some good vitamin/mineral supplements, stay off their phones while driving, wear seatbelts, get enough sleep, etc —- in other words, simply take decent care of themselves.
Given the state of health care in this country, I feel like getting your genome sequenced is a really bad idea. My first question to the genetic counselor when I was tested for the BRCA mutation was “Tell me about privacy and insurance concerns”. So Nicole made a good choice in withholding her last name. But once that information is out there, it’s out there. You can’t put the genie back in the bottle.
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