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This is a lightly edited transcript from a recent episode of STAT’s biotech podcast, “The Readout LOUD.” Like it? Consider subscribing to hear every episode.

Over the past decade, more than 25 million people have ordered at-home DNA testing kits from companies like 23andMe and Ancestry.com. You spit in a tube, send it away, and get notified by email when your results are ready. Initially aimed at providing information about ancestry, some companies now test for certain genetic mutations that are strongly correlated with the risk of developing cancer, Alzheimer’s disease, or other serious conditions.

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