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The proprietary chemistry technology at Wave Life Sciences is designed to create “stereopure” versions of RNA-based drugs that are more potent, safer, and longer-lasting than similar RNA drugs from other companies. On Monday, however, the Cambridge, Mass.-based biotech’s most crucial clinical test of its platform yielded very disappointing results.

In a study involving patients with Duchenne muscular dystrophy, 12 weeks of treatment with the Wave drug called suvodirsen failed to increase levels of dystrophin compared to baseline, the company said.

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