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SAN FRANCISCO — There are numerous startups trying to help patients better adhere to their medication regimens, whether by developing smart pill bottles, devising monitoring systems for clinical trials, or asking patients to take selfies as they swallow a pill. But there appear to be only two companies tackling the issue with sensor technology to track when pills get ingested — with the goal of improving their outcomes.


The first, and best known, is Proteus Digital Health, which has raised close to $500 million over the past two decades. In recent weeks, the struggling Silicon Valley-based company has laid off employees, abandoned its work in mental health and on cardiovascular conditions, and lost a co-development partnership with the pharma company Otsuka.

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