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Tumors shrank in one quarter of patients with advanced lung cancer who received a bespoke cell therapy made by doctors at H. Lee Moffitt Cancer Center in Tampa, Fla. In two patients, the researchers found, lung tumors disappeared completely.

Though the study was small, the results are impressive because the patients had tumors in their lungs that were not responding to Opdivo, one of the checkpoint-inhibitor immunotherapies that are now standard of care. That makes these patients particularly difficult to treat effectively.

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