When major decisions must be made amid high scientific uncertainty, as is the case with Covid-19, we can’t afford to silence or demonize professional colleagues with heterodox views. Even worse, we can’t allow questions of science, medicine, and public health to become captives of tribalized politics. Today, more than ever, we need vigorous academic debate.

To be clear, Americans have no obligation to take every scientist’s idea seriously. Misinformation about Covid-19 is abundant. From snake-oil cures to conspiracy theories about the origin of SARS-CoV-2, the virus that causes the disease, the internet is awash with baseless, often harmful ideas. We denounce these: Some ideas and people can and should be dismissed.

At the same time, we are concerned by a chilling attitude among some scholars and academics, who are wrongly ascribing legitimate disagreements about Covid-19 to ignorance or to questionable political or other motivations.

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A case in point involves the response to John Ioannidis, a professor of medicine at Stanford University, who was thrust into the spotlight after writing a provocative article in STAT on Covid-19. He argued in mid-March that we didn’t have enough information on the prevalence of Covid-19 and the consequences of the infection on a population basis to justify the most extreme lockdown measures which, he hypothesized, could have dangerous consequences of their own.

We have followed the dialogue about his article from fellow academics on social media, and been concerned with personal attacks and general disparaging comments. While neither of us shares all of Ioannidis’ views on Covid-19, we both believe his voice — and those of other legitimate scientists — is important to consider, even when we ultimately disagree with some of his specific analyses or predictions.

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We are two academic physicians with different career interests who sometimes disagree on substantive issues. But we share the view that vigorous debate is fundamental to the existence of universities, where individuals with different ideas who have a commitment to reason compete to persuade others based on evidence, data, and reason. Now is the time to foster —not stifle — open dialogue among academic physicians and scientists about the current pandemic and the best tactical responses to it, each of which involve enormous trade-offs and unanticipated consequences.

Since Covid-19 first emerged at the end of 2019, thousands of superb scientists have been working to answer fundamental, vital, and unprecedented questions. How fast does the virus spread if left unabated? How lethal is it? How many people have already had it? If so, are they now immune? What drugs can fight it? What can societies do to slow it? What happens when we selectively evolve and relax our public health interventions? Can we develop a vaccine to stop it? Should governments mandate universal cloth masks?

For each of these questions, there are emerging answers and we tend to share the consensus views: Without social distancing, Covid-19 would be a cataclysmic problem and millions would die. The best current estimate of infection fatality rates may be between 0.4% and 1.5%, varying substantially among age groups and populations. Some fraction of the population has already been infected by SARS-CoV-2 and cleared the virus. For reasons that aren’t yet totally clear, rates of infection have been much higher in Lombardy, Italy, and New York City than in Alaska and San Francisco. To date no drug has shown to be beneficial in randomized trials — the gold standard of medicine. And scientists agree that it will likely take 18 months or longer to develop a vaccine, if one ever succeeds. As for cloth masks, we see arguments on both sides.

At the same time, academics must be able to express a broad range of interpretations and opinions. Some argue the fatality rate will be closer to 0.2% or 0.3% when we look back on this at a distance; others believe it will approach or eclipse 1%. Some believe that nations like Sweden, which instituted social distancing but with fewer lockdown restrictions, are pursuing the wisest course — at least for that country — while others favor the strictest lockdown measures possible. We think it is important to hear, consider, and debate these views without ad hominem attacks or animus.

Covid-19 has toppled a branching chain of dominoes that will affect health and survival in myriad ways. Health care is facing unprecedented disruption. Some consequences, like missed heart attack treatment, have more immediate effects while others, like poorer health through economic damage, are no less certain but their magnitude won’t immediately become evident. It will take years, and the work of many scientists, to make sense of the full effects of Covid-19 and our responses to it.

When the dust settles, few if any scientists — no matter where they work and whatever their academic titles — will have been 100% correct about the effects of Covid-19 and our responses to it. Acknowledging this fact does not require policy paralysis by local and national governments, which must take decisive action despite uncertainty. But admitting this truth requires willingness to listen to and consider ideas, even many that most initially consider totally wrong.

A plausible objection to the argument we are making that opposing ideas need to be heard is that, by giving false equivalence to incorrect ideas, lives may be lost. Scientists who are incorrect or misguided, or who misinterpret data, might wrongly persuade others, causing more to die when salutatory actions are rejected or delayed. While we are sympathetic to this view, there are many uncertainties as to the best course of action. More lives may be lost by suppressing or ignoring alternate perspectives, some of which may at least in part ultimately prove correct.

That’s why we believe that the bar to stifling or ignoring academics who are willing to debate their alternative positions in public and in good faith must be very high. Since different states and nations are already making distinct choices, there exist many natural experiments to identify what helped, what hurt, and what in the end didn’t matter.

We believe that the bar to stifling or ignoring academics who are willing to debate their alternative positions in public and in good faith must be very high.

Society faces a risk even more toxic and deadly than Covid-19: that the conduct of science becomes indistinguishable from politics. The tensions between the two policy poles of rapidly and systematically reopening society versus maximizing sheltering in place and social isolation must not be reduced to Republican and Democratic talking points, even as many media outlets promote such simplistic narratives.

These critical decisions should be influenced by scientific insights independent of political philosophies and party affiliations. They must be freely debated in the academic world without insult or malice to those with differing views. As always, it is essential to examine and disclose conflicts of interest and salient biases, but if none are apparent or clearly demonstrated, the temptation to speculate about malignant motivations must be resisted.

At this moment of massive uncertainty, with data and analyses shifting daily, honest disagreements among academic experts with different training, scientific backgrounds, and perspectives are both unavoidable and desirable. It’s the job of policymakers, academics, and interested members of the public to consider differing point of views and decide, at each moment, the best courses of action. A minority view, even if it is ultimately mistaken, may beneficially temper excessive enthusiasm or insert needed caveats. This process, which reflects the scientific method and the culture that supports it, must be repeated tomorrow and the next day and the next.

Scientific consensus is important, but it isn’t uncommon when some of the most important voices turn out to be those of independent thinkers, like John Ioannidis, whose views were initially doubted. That’s not an argument for prematurely accepting his contestable views, but it is a sound argument for keeping him, and others like him, at the table.

Vinay Prasad is a hematologist-oncologist and associate professor of medicine at the Oregon Health and Science University and author of “Malignant: How Bad Policy and Bad Evidence Harm People with Cancer” (Johns Hopkins University Press, April 2020). Jeffrey Flier is an endocrinologist, professor of medicine, and former dean of Harvard Medical School.

  • Thanks for a generally good article. I hope you don’t mind a little gentle push-back here.

    In amongst a number of statements of legitimate criticism,
    though I haven’t look that hard, I have only found one tweet and one youtube comment casting doubt on Dr. Ioannidis’s motivations.
    I for one do not. Best to avoid ascribing inappropriate motivations to scientists without strong evidence.
    But I was listening to Dr. Prasad’s excellent Plenary Session podcast in which he claimed that Harvey Fineberg wrote his NEJM column because he wanted to see his name in print. I don’t think that’s true.

    I have followed and agreed with Prasad’s criticisms of “key opinion leaders” and other big shots receiving inappropriate credence based on prestige.
    Dr. Ioannidis might be receiving a little excess credence here for that reason.

    So in summary, it’s complicated and we all might tread lightly.

  • Thank you. It’s been driving me crazy when people apparently seem to think that we need to either minimize transmissions of the disease OR minimize risks of poverty. Both unrestrained spread of Covid-19 AND rampant poverty seem terrible to me. Could it be the two aren’t mutually exclusive? Is it possible both camps are right (and simultaneously wrong)? Are there ways to allow meaningful economic activity while at the same time inspiring, empowering, and incentivizing everyday people to passionately prevent disease transmissions? If not, why not?

  • Hey STAT, you should note when a piece has been edited post publication – in this case, removal of the reference to Carl Bergstrom’s Twitter feed.

  • Yeah, we’re not really in a good space in 2020 to divorce anything from its political impact and, while those on the other side of our current deep divide will contest this bitterly, I feel the blame here lies with Fox News and Fox News’ biggest fan, the POTUS. We are living in some kind of alternate universe where, to take just ONE example, Fox News prime time hosts **relentlessly** promoted Hydroxychloroquine as something that people infected with COVID-19 should be consuming, followed of course by Trump then **also** promoting it, all with no testing having demonstrated efficacy. When people are suffering and dying, it doesn’t matter how apolitical a theory is claimed to be if it feeds into a disgusting and dangerous false narrative being blasted by right-wing media and the Trump Administration. In the ugly world we are living in the middle of, there is **nothing** that is not political. I say your argument, while founded on serious best intentions, is misplaced and ground into irrelevance by our evil POTUS and his enablers. In a more sane time, maybe that would not be true.

    • So, no one is listening to the science, eh? The ventilator question is my first thought after reading this. Science is in flux…not knowing where the answers will fall. It takes a lot of guts to put your ideas out there based on your observations
      and understanding alone, with few if any statistics to back them up. It’s the way new science always begins, by sticking your neck out not knowing how your ideas will be perceived. The cranks are usually flushed out pretty quickly. But those ideas that survive….change everything. You may or may not have noticed that science moves on, regardless of what Trump says or does. Very important article, to me.

  • I have an idea why there is an increased effort to stifle minority scientific viewpoints. University administration and faculty is generally rather left leaning politically. In the past decade or so the left has used basic censorship to quash ideas which do not comport to its own. They have found this method to be very effective. What has happened is that this method is now rubbing off on even science. The non-majority view is treated similarly to the right wing political view on campus. It is censored and subjected to terrible name calling. This will be a tough one to break through until we decide that any censorship of robust debate at academic institutions is a very bad idea and stop doing it.

  • Thank you so much for this article. It is very difficult to attempt navigating a middle ground in a landscape where so many prefer to fully err on one side or the other, no matter the consequences. If I show any doubt towards a full lock down of the nation, I am branded as “Trump parrot”, “climate change denier”, “anti-vaxer”, and “flat earther”. But if I come to the defense of the data reported by the C.D.C. or the W.H.O., I am lectured on the errors each has made in the interest of the nations and political parties to which they are beholden. This article has provided a calm harbor amidst a tossing sea of polar view points; again, thank you.

  • Great article! This is an interesting issue to talk about.
    Here in Brazil, looks like we are about 3 weeks behind the US in question of numbers. I hope the pandemic doesn’t get as worse as it is in the US or Italy.
    And, in the midst of this, there are scientists discussing the best way to face the problem. And I think everyone should be heard. And not fight with each other.
    For regular people like me, non scientist, I would like to know all parts.
    My company, Real Gramas, has dropped business a lot but we are kinda surviving. Hope all gets better soon.
    Real Gramas

  • The problem comes when technical medical differences are argued in the general public forum. Many average people simply do not have the prerequisite knowledge to assess these differences in a meaningful way. Instead, many cling to the positions that resonate with their prejudices and ignore those that challenge them. This serves no ones’ interests, provides no light or guidance; it just fuels discord.

    We scientists have an obligation to keep open minds, to listen carefully to differing points of view, and to make judgments based on the data. Where sufficient data doesn’t exist, the precautionary principle should be our guide.

    • Good luck on that one! Politics is busy overwhelming everything. Everything is treated as a political argument and until that lightens up what you see is what you will continue to get.

  • The main issue in scientific communication I’ve seen is the tendency of risk-aversion to confound statements about probability. For instance, the infamous “scientists don’t know yet” phrase is misinterpreted by many as “scientists doubt” out of fear. Health regulators say “no evidence” when they actually mean “insufficient evidence”. This all comes from a fundamental failure in the human mind to separate risk-aversion from probability. Small probabilities of negative scenarios become highly inflated in policy discussions. We have to be careful when communicating to accurately describe both expectations and fears.

  • Excellent article! As a nurse I spend much of time of late explaining to people don’t stay home when you are having chest pain, slurred speech, etc. The fear that has been promoted is killing people who we might have saved if they had come to the ER. It frustrates me to see even educated persons running away from healthcare even in a emergency because of the outlandish scare. Then you have the other swing of the pendulum where people won’t keep their distance. Common sense, where did it go?
    Thank you for the something that actually makes sense.

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