Contribute Try STAT+ Today

We’ve evolved elegant protections for our brains. Gray matter deftly avoids contact with most interlopers, thanks to an intricate cellular shrink wrap called the blood-brain barrier. But this defense system creates its own challenges for us: It’s been extraordinarily difficult to design medicines that can target neurological illness.

There’s hope that could change, though. A duo of preclinical studies led by Denali Therapeutics recently demonstrated a new way to ferry medicines past the blood-brain barrier. The San Francisco biotech engineered antibody fragments, with medicinal payloads attached to them, that can slip through molecular gateways in the brain’s cellular lining.

Unlock this article by subscribing to STAT+ and enjoy your first 30 days free!


What is it?

STAT+ is STAT's premium subscription service for in-depth biotech, pharma, policy, and life science coverage and analysis. Our award-winning team covers news on Wall Street, policy developments in Washington, early science breakthroughs and clinical trial results, and health care disruption in Silicon Valley and beyond.

What's included?

  • Daily reporting and analysis
  • The most comprehensive industry coverage from a powerhouse team of reporters
  • Subscriber-only newsletters
  • Daily newsletters to brief you on the most important industry news of the day
  • STAT+ Conversations
  • Weekly opportunities to engage with our reporters and leading industry experts in live video conversations
  • Exclusive industry events
  • Premium access to subscriber-only networking events around the country
  • The best reporters in the industry
  • The most trusted and well-connected newsroom in the health care industry
  • And much more
  • Exclusive interviews with industry leaders, profiles, and premium tools, like our CRISPR Trackr.