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As part of President Trump’s treatment, he was given dexamethasone, a powerful steroid. But how does dexamethasone work? And why did its use fuel speculation about both the severity of Trump’s disease and its effect on his mood after his release from the hospital?

Some of the most serious cases of Covid-19 are the result of an overreaction of a patient’s own immune system to the virus that causes the disease. This response, called a “cytokine storm,” can cause immune cells to attack not only the virus, but healthy tissues as well. Cytokine storms can cause permanent damage to the lungs, and in some cases, prove deadly. 

That’s why dexamethasone is sometimes used as a treatment. It makes such an overreaction less likely by suppressing the body’s immune system. But the use of the drug comes with risks. If given too early, it can weaken the immune system when a patient needs it most. 


The steroid has been used for decades to treat a wide variety of ailments. It is inexpensive and widely prescribed. But side effects of dexamethasone can be quite serious. It is not uncommon for people treated with dexamethasone to display aggression, anxiety, or mood swings. 

Watch our video above for a quick look at how dexamethasone works.

  • The steroid is out of Trump’s system so I don’t see why anyone is concerned about the side effects in him at this point. I’ve used that drug several times. It is more common that people do not have mood affecting side effects.

    We should be thankful that our President pulled through quickly so we did not need to add a dead or dying President to our country’s woes at this time.

    • The man has been showing too many signs if diminished mental faculties for a long time. I think that factoring in his age, weight, diet and other detrimental lifestyle factors would and probably has contributed to his current memory lapses and cognitive abilities is just as important.

  • His moods change moment to moment, & aggression should be his middle name….so how do Dr’s tell if he’s having side effects? ??

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