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South Africa is halting its rollout of the AstraZeneca-University of Oxford Covid-19 vaccine, the country’s minister of health said Sunday, following a new analysis that suggests the shot “provides minimal protection” against mild disease caused by the new coronavirus variant circulating in South Africa.

Two top virologists advising the government said during a press conference that the pause was necessary. They said South Africa would institute a new process in which vaccines are initially studied in a research phase to try and determine that each vaccine reduces Covid hospitalizations in South Africa despite the widespread new variant there.

“The AstraZeneca vaccine rollout needs to be put on a temporary halt while we get the clinical efficacy information in,” said Salim Abdool Karim, an epidemiologist at Columbia University and part of a commission advising the South African government. “And the way that we can do that is with the new approach to rollout.”

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Barry Schoub, chair of South Africa’s Ministerial Advisory Committee on vaccines, struck a similar note.

“I think we just need to maybe suspend use of AstraZeneca, but investigate it more and more fully to see, can we utilize it more effectively,” he said.

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The news heightens concerns about B.1.351, the variant first seen in South Africa, and will also likely lead to discussions about the effectiveness of the AstraZeneca-Oxford vaccine, which is among the least expensive and most widely available of the Covid-19 vaccines that have so far been developed. In addition to AstraZeneca, the vaccine is also being made for much of the world by Serum Institute, a large Indian vaccine maker.

However, the data, which were presented in detail during the livestreamed press conference, do not give clear answers. The results involve only small numbers of patients and may not be enough to draw any conclusions. The data were also submitted as a preprint and have not yet been peer-reviewed.

Shabir Madhi, professor of vaccinology at the University of the Witwatersrand and chief investigator on the new study, said that before B.1.351 became common in South Africa, the vaccine was trending toward reducing mild cases of disease by 75%. But once B.1.351 became prevalent, that number dropped precipitously, and cases were reduced only 22% based on 42 cases of symptomatic Covid.

Those data appear unreliable, however. They were given with confidence intervals, which propose a range of plausible outcomes. For the 22% number, those ranged from -50% to 60%, meaning that more data would be needed to be collected to trust the figure.

Researchers and AstraZeneca emphasized in separate statements that the study was a small one, including only 1,765 volunteers with a median age of 31. AstraZeneca said it believes the vaccine will still protect against severe disease caused by B.1.351. The current study gives no information on whether the vaccine prevents severe disease, hospitalization, or death.

AstraZeneca also said that it and Oxford have started adapting their vaccine to B.1.351, and will advance the new vaccine through development so that it is ready for delivery in the fourth quarter of the year if it is needed.

This is the third vaccine, and the first approved vaccine, to show what appears to be reduced efficacy against B.1.351. Johnson & Johnson said that its vaccine, which was 66% effective overall against moderate-to-severe disease, was 57% effective against moderate-to-severe disease due to the variant. Novavax, another vaccine developer, said that its vaccine was 89% effective against mild-to-moderate disease, but in a separate trial in South Africa was 50% effective.

Karim pointed out that only the Johnson & Johnson vaccine has been shown to reduce severe disease due to B.1.351. He said that when vaccines are rolled out, South Africa will now look at hospitalization rates in the first 100,000 to receive the vaccine in the hopes that this will provide information on whether the vaccine is proving effective.

Madhi warned that it could be “reckless” to simply let doses of the AstraZeneca vaccine expire without giving them, given the possibility that the vaccine could reduce severe disease.

  • I use to ask my self that why does Mr president and his government did not close the borders from the first time they that there is a virus coming from ather countrys,what was the main reason of doing that,and now they have got information already that another virus is coming, there is nothing to tell where does this virus coming from.the only that they are is to this that if the virus I here started killing people,what is going to be son.it seem like we will be staying with this virus for ever,we will be wearing musk for ever.what is really going in this country

  • How did this vaccine come in South Africa without clear assement. How will the other one be trusted. Our senior must start then we will follow.

  • There is no evidence that this vaccine is ineffective against serious disease. The report is being published today and it would be wise to read that before jumping to conclusions since there are all sorts of variables that could affect the results (time between doses for example). Professor Sarah Gilbert, the lead Oxford vaccine designer, said that they were confident their vaccine would still protect against serious disease caused by the South African variant. Whether or not this is correct will become apparent shortly of course. If this does prove to be the case then these findings seem to be following the same pattern as that shown by the Novovax and Jansen vaccines. As you have reported, Oxford University are using platform technology in order to tweak the vaccine in order to improve efficacy against both the South African and Brazilian variants. Professor Gilbert said on the BBC yesterday that she hoped the modified vaccine would be available by the autumn.
    With regard to your comment about questions on the general efficacy of the vaccine, I don’t think this will happen. I would mention that recent data points to this vaccine being far more effective than the early results published in November indicated. In addition, it was reported by Oxford last week that their vaccine was equally effective against the B117 (Kent/British) variant. It is also the only vaccine so far that appears to reduce transmission of the disease which is really exciting.

  • South African strain’s genomes may become extremely unstable, thus to destroy vaccine efficacy to make virus become much smarter and virulent simultaneously, speeding up mutations.

  • Since you think Covid-19 is insignificant, be sure to not get vaccinated so there will be one more dose available for someone with a bit more common sense.
    After you’re infected & possibly get severe symptoms, also no need to take up any hospital bed space since SARS-CoV-2 is insignificant.

  • So efficacy test failed. Now at least they can properly check for side effects. And perhaps go back to square one and ask, “Do we really have a pandemic?” – more cancer, heart, other deaths, abortions pale covid-19 into insignificance

    • Since you think Covid-19 is insignificant, be sure to not get vaccinated so there will be one more dose available for someone with a bit more common sense.
      After you’re infected & possibly get severe symptoms, also no need to take up any hospital bed space since SARS-CoV-2 is insignificant.

  • Seems more investigations need to be done beyond the two challenges mentioned before rollout.

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