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Sage Therapeutics said Monday that its experimental pill was more effective than a placebo in treating patients with essential tremors, a neurological condition that causes involuntary, rhythmic muscle shaking, in a mid-stage trial.

But a high starting dose of the drug was not well tolerated. More than 60% of patients had to switch to lower doses of the treatment, called SAGE-324, because of side effects, including sleepiness and drowsiness.

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