Skip to Main Content

This week’s “First Opinion Podcast” is a special two-part episode focusing on the controversial — some say inflammatory — FDA decision to approve aducanumab, an Alzheimer’s drug developed by Biogen that will be marketed as Aduhelm. In these two episodes, I talk with two Alzheimer’s experts with vastly different viewpoints on the news: Dennis Selkoe, a physician and scientist whose research is at the core of how Aduhelm works; and Jason Karlawish, an Alzheimer’s physician who does not believe the drug is ready to be approved.



Selkoe wrote a First Opinion in 2019 on how research on aducanumab could “open the floodgates” for other, possibly better, Alzheimer’s therapies. The headline of Karlawish’s First Opinion, published a week before the long-awaited FDA decision, succinctly captured his stance: “If the FDA approves Biogen’s Alzheimer’s treatment, I won’t prescribe it.

For even more coverage of the Biogen news, listen to the latest episode of “The Readout LOUD.”

Be sure to sign up for the weekly “First Opinion Podcast” on Apple PodcastsStitcherGoogle Play, or wherever you get your podcasts.


And if you have any feedback for us — First Opinion authors to feature on the podcast, vocal mannerisms the host needs to jettison, kudos or darts — email us at [email protected] and please put “podcast” in the subject line.

Create a display name to comment

This name will appear with your comment

There was an error saving your display name. Please check and try again.