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Seres Therapeutics has announced a new deal with its longtime partner, Nestlé Health Science, to bring Seres’ lead experimental microbiome drug to the U.S. market. That drug, SER-109, has been tested to treat the potentially lethal bacteria C. difficile.

The deal, announced Thursday, is worth $175 million upfront, with more than $300 million more in milestone payments. Each company will split the profits from the drug sales down the middle.

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