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WASHINGTON — For the cadre of progressive groups fighting to bring down drug prices in a big way, this week was a massive setback.

The broad coalition, which includes consumer advocates, employers, and labor unions, was blindsided Wednesday when a trio of moderate House Democrats formally opposed Speaker Nancy Pelosi’s sweeping drug pricing package — a consequential move, since Democrats’ razor-thin majority means that even three opponents could force leadership to water down or abandon an otherwise popular policy.

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