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WASHINGTON — Lawmakers are within striking distance of closing the largest loophole in the Food and Drug Administration’s oversight of e-cigarette companies — a move that would likely put the biggest driver of youth vaping out of business in the process.

A draft of a government spending bill obtained by STAT includes new language that would give the FDA explicit authority to regulate so-called synthetic nicotine products, which are made in a lab rather than extracted from tobacco plants, and currently are not regulated by the FDA.

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