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Cassava Sciences conceded Tuesday that only a relative handful of patients with Alzheimer’s have been enrolled in its late-stage clinical trials — a sign that ongoing investigations over the credibility of its experimental drug simufilam have made physicians and patients wary.

On a company-sponsored webcast, Cassava CEO Remi Barbier said 60 patients have begun treatment across its two Phase 3 clinical trials. The studies, which randomize patients to receive either simufilam or a placebo, have been expected to enroll 1,750 patients.

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