Skip to Main Content

Researchers reported Wednesday that they could quickly and reliably turn CAR-T cells on and off in cancer patients, giving scientists an unprecedented level of control over this potent — but at times dangerous — oncology therapy.

The findings, presented at the CAR-TCR Summit in Boston, come from an early-stage clinical trial by Scripps Research of patients with B cell cancers. Seven of the first nine participants treated in the ongoing study have responded to the so-called “switchable” CAR-T cells, which have been engineered to only attack cancer cells when combined with an antibody that acts as a switch that unlocks the therapy. Six of these patients have had complete responses, meaning that researchers can no longer spot signs of cancer.

Unlock this article by subscribing to STAT+ and enjoy your first 30 days free!


Create a display name to comment

This name will appear with your comment