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H.T. Begay is a happy kid. He’s smiley, silly, and definitely trying to make you laugh. The four-year-old’s two neat braids of dark hair wave behind him as he runs among the dust, dogs, and sheep near his family’s ranch on their Navajo reservation in Arizona.

On a table inside the family’s sweat lodge is a little altar, as shown in a video shared by the University of California, San Francisco. Next to a pair of tiny baby booties is a certificate that reads, “The first patient in the world to receive Autologous Gene Therapy for Artemis-deficient SCID 06/23/2018.”

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