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SAN FRANCISCO — The last time Sana CEO Steve Harr was here for the J.P. Morgan Healthcare Conference, his company had only recently shrugged off the unprintable code name its founders used privately: FD Therapeutics, short for “F— Disease.” Little was known about the then-mysterious cell therapy startup, except that it would pursue ideas “that will seem unconnected to the current reality” and, rumor had it, potentially raise an over $1 billion Series A.

Today, Sana is a public company. It did raise prodigious sums, $700 million in a Series A and another $585 million in an IPO. Yet disease — well, disease remains with us.

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The biotech’s hopes to be in clinical trials by 2022 have lapsed. In November, it shelved an ambitious program to regenerate heart cells and laid off 15% of its staff. Its stock is down 85%, victim of a cold biotech market particularly cruel to ambitious companies with no human data.

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