Skip to Main Content

SAN DIEGO  — Travere Therapeutics, a biotech focused on treating rare diseases, on Monday announced that a Phase 3 trial of an experimental treatment for focal segmental glomerulosclerosis, a rare and deadly kidney disease, failed to improve kidney function.

In the 371-person study, half of patients were randomly assigned to receive the drug, known as sparsentan, while the other half received irbesartan, a blood pressure treatment used as a control. Both groups were monitored for two years, and while the study’s main measurement — average kidney function — was higher among patients on sparsentan compared to the placebo group, the finding was not statistically significant.


Other secondary measures, such as urine protein levels, were lower among those on the drug, pointing in the right direction, and the company told investors and analysts in a conference call on Monday that the therapy was generally safe.

Unlock this article by subscribing to STAT+ and enjoy your first 30 days free!


Create a display name to comment

This name will appear with your comment

There was an error saving your display name. Please check and try again.