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Drug makers around the globe are moving at breakneck speed to advance their Covid-19 vaccine and therapeutic candidates. The race has made one thing clear: The path toward scientific progress will come with bumps in the road.

Here’s a guide to some of the most talked-about efforts to treat or prevent coronavirus infection, with details on the science, history, and timeline for each endeavor (and we will update the tracker with any new developments). We’re looking at novel medicines, not repurposed drugs. (For more on some of the efforts to repurpose drugs, read this.) The below therapies and vaccines are sorted in order of how close they could be to approval, starting with a treatment in Phase 3 trials, followed by others in Phase 1 studies and then preclinical development. Approval, of course, would only come if they are proven safe and effective.

— Damian Garde

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